2020年2月4日 · Here we identify a novel and critical function of IKK2 and its co-factor NEMO in the activation of oncogenic c-Jun N-terminal kinase (JNK) signaling, induced by the latent membrane protein 1...

2014年11月20日 · JNK activation increases spontaneous action potential firing of AgRP cells and causes both neuronal and systemic leptin resistance. Similarly, activation of IKK2 signaling in AgRP neurons also increases firing of these cells but fails to cause obesity and leptin resistance.

IKK是一种常见的 转录因子 激活蛋白 [1]，可以被位于 细胞质膜 的 TNF -TNFR复合体、 IL -ILR复合体、活化的 Toll样受体 、 病毒感染 和胞外电离辐射激活。 常见的 炎症因子 (包括IL-α和TNF-α等)都可以参与激活IKK。 NF-κB 由两类 亚基 形成的 异源二聚体，一类亚基包括p65，另一类亚基为p50。 NF-κB未被激活时和 IκB -α形成一个复合物，分布在细胞浆中。 在炎症因子、 生长因子 或 趋化因子 等可以激活IKK的情况下，IκBkinase (IKK)复合物会被NF-κB-inducingkinase磷酸 …

1999年12月1日 · Both IKKβ and JNK2 are essential for efficient induction of type I IFN and other cytokines in response to viral infection or dsRNA. This study establishes a general role for these kinases in activation of innate immune responses.

2001年7月19日 · We find that the TAK1 kinase complex phosphorylates and activates IKK in a manner that depends on TRAF6 and Ubc13–Uev1A. Moreover, the activity of TAK1 to phosphorylate MKK6, which activates the...

LMP1 via IKK2 and transmits JNK activation signals downstream of IKK2. The IKK2-TPL2-JNK axis is specific for LMP1 and differs from TNFα, Interleukin−1 and CD40 signaling.

This review summarizes recent advances in TNF-alpha signaling mechanisms that demonstrate how the IKK, ROS, and JNK pathways interact with each other to regulate hepatocyte apoptosis and proliferation.

The IKK kinase complex is the core element of the NF-κB cascade. It is essentially made of two kinases (IKKα and IKKβ) and a regulatory subunit, NEMO/IKKγ. Additional components may exist, transiently or permanently, but their characterization is ...

IκB激酶（IKK）信号通路与c-Jun 氨基末端蛋白激酶（JNK）信号通路对机体的炎症反应起着中枢调控作用，本研究前期工作发现，IKK与JNK可分别促进老年小鼠T细胞和肝细胞炎症反应的发生，是炎性衰老的重要调节者。 因此，本研究拟以IKK、JNK信号通路与炎性衰老关系为切入点，通过比较年轻与衰老小鼠免疫细胞中IKK通路关键调控蛋白TRAF2/6、TAK1及相关信号调控网络的变化，肝脏等组织中JNK通路关键调控蛋白Mule、Miz1及相关信号调控网络的变化，在整体、组 …

The inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex is the master regulator of the NF-κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly stimulus-specific, and target-specific event that is essential for ...