SIGIRR：一个新的信号受体TIR超家族成员，机体炎症、免疫反应 …
单免疫球蛋白白细胞介素1受体相关蛋白（Single Ig IL-1-related receptor，SIGIRR），又称白细胞介素1受体8（Interleukin-1 receptor8，IL-1R8），于1999年由Thomassen等首次发现并命 …
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti ...
2017年11月2日 · Here we report that IL-1R8 serves as a checkpoint for NK cell maturation and effector function. Its genetic blockade unleashes NK-cell-mediated resistance to hepatic …
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti ...
2017年10月25日 · Here we report that IL-1R8 serves as a checkpoint for NK cell maturation and effector function. Its genetic blockade unleashes NK-cell-mediated resistance to hepatic …
IL-1R8 is a checkpoint in NK cells regulating anti-tumor and anti …
Here we report that IL-1R8 serves as a checkpoint for NK cell maturation and effector function. Its genetic blockade unleashes NK-cell mediated resistance to hepatic carcinogenesis, …
IL-1R8: A molecular brake of anti-tumor and anti-viral activity of …
2023年3月1日 · IL-1R8 (also known as TIR8 or SIGIRR) is a member of the IL-1R family that acts as a negative regulator dampening ILR and TLR signaling and as a co-receptor for human IL …
Regulatory Role of IL-1R8 in Immunity and Disease - Frontiers
2016年4月19日 · IL-1R8 is a component of the receptor recognizing human IL-37. Here, we summarize our current understanding of the structure and function of IL-1R8, focusing on its …
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to ... - Nature
2015年3月2日 · Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively. Here we demonstrate …
去泛素化酶USP13稳定抗炎受体IL-1R8/Sigirr以抑制肺部炎症
2023年8月18日 · 白细胞介素-1（IL-1）相关受体（Sigirr），也被称为IL-1R8，已被证明对包括急性肺损伤在内的炎症性疾病有广泛的抗炎作用，而IL-1R8/Sigirr蛋白稳定性的分子调控尚未有 …
IL-1R8: A molecular brake of anti-tumor and anti-viral ... - PubMed
IL-1R8 (also known as TIR8 or SIGIRR) is a member of the IL-1R family that acts as a negative regulator dampening ILR and TLR signaling and as a co-receptor for human IL-37. Human and …
IL-1R8 silencing improves the anti-tumor function of freshly …
The inhibitory receptor interleukin-1 receptor 8 (IL-1R8) has been recently recognized to be expressed also by human natural killer (NK) cells. This study was aimed to design and …