Interleukin 27 (IL-27) is a member of the IL-12 cytokine family. It is a heterodimeric cytokine that is encoded by two distinct genes, Epstein-Barr virus-induced gene 3 (EBI3) and IL-27p28. IL-27 is expressed by antigen presenting cells and interacts with a specific cell-surface receptor complex known as IL-27 receptor (IL-27R).

2017年9月4日 · IL-27 是由 EBI3 和 p28 亚单位通过二硫键构成的异源二聚体。 IL-27 可以促进 Th1 和 Tr1 分化, 抑制 Th2、Th17 及 Treg 应答, 在免疫调节方面具有重要作用。 IL-27 属于 IL-12 家族成员, 主要由抗原提呈细胞, 包括树突状细胞、巨噬细胞等在微生物或其他免疫刺激物刺激下产生, 其受体广泛分布于多种免疫细胞. IL-27 信号通过细胞上的异源二聚体受体 IL-27R 传导至胞内。 IL-27R 由 WSX-1 和 gp130 亚基构成。 WSX-1 和 gp130 可以在包括 T 细胞、NK 细胞、B 细 …

2025年2月5日 · Our data demonstrate that endogenous IL-27 is essential for anti-tumour immunity and that IL-27 receptor agonism can safely improve anti-tumour T cell responses alone or in combination with...

白细胞介素27 (interleukin 27, IL-27)作为一种多效 性的双链细胞因子，多项动物和临床研究显示其在 免疫相关疾病中发挥重要作用[10–13]。 IL-27 主要由抗原递呈细胞 (antigen-presenting cells, APC) 产生，与其受体IL-27R 结合后，主要通 过Janus 激酶(Janus kinase, JAK)/信号转导子 ...

2024年12月25日 · IL27 (Interleukin 27) is a Protein Coding gene. Diseases associated with IL27 include Neurosyphilis and Toxoplasmosis. Among its related pathways are IL27-mediated signaling events and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and interleukin-27 receptor binding.

Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune response. Although it was initially linked with the development of Th1 responses, it is now recognized as a potent antagonist of different classes of inflammation through its ability to …

IL-27作为一种具有独特免疫学优势的调节因子，未来在肿瘤免疫治疗中的应用前景广阔。 肿瘤免疫治疗已是癌症治疗的重要方向，尤其是免疫检查点 ...

Interleukin (IL)-27, a member of the IL-6/IL-12 family, has an important role in modulating inflammation in partnership with innate and adaptive immune cells. IL-27 binding to IL-27R starts downstream signaling based on the target cells.

IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4 + T cells. It also strongly synergizes with IL-12 to trigger IFN-γ production of naive CD4 + T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR.

IL-27 is a pleiotropic cytokine that has diverse immune regulatory activities under both physiological and pathological conditions. IL-27 enhances the functions of Th1 and CD8 + T cells, promotes the development of Tfh and Tr1, and suppresses the …