Interleukin 32 (IL-32) is a pro-inflammatory cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and IL-6. In addition, it can also induce the production of chemokines such as IL-8 and MIP-2 / CXCL2. [6]

2024年9月6日 · 本文总结了il-32与多种炎症和肿瘤相关疾病的最新研究进展，旨在从il-32含量的动态变化的角度探讨炎症与恶性肿瘤的发病分子机制，以期通过整合现有证据，加深对il-32在多种炎症相关疾病和肿瘤中发挥作用的机制认识。

2017年9月3日 · IL-32 是一种新的促炎性细胞因子，在人和小鼠细胞内通过 NF-B 和蛋白激酶 P38MAPK 信号途径激活多种炎症因子（如 TNF,IL-1，IL-6 等）和趋化因子的表达。 临床研究显示 IL-32 在许多慢性炎症性疾病如类风湿性关节炎，炎性肠病中起重要作用，而 IL-32 是其最活跃的亚型。 在类风湿性关节炎纤维样滑膜细胞中 IL-32 经 TNF-α和 poly;c 刺激后其 mRNA 水平升高，但无蛋白分泌，而 Shioya 等，却发现某些上皮细胞可分泌 IL-32 蛋白，这可能于细胞的类型有 …

2020年9月20日 · IL⁃32诱导肿瘤细胞产生肿瘤坏死因子α （tumor necrosis factor⁃α， TNF⁃α）， 增强原发性胰腺癌的生长和侵袭能力； IL⁃1β通过级联反应， 放大炎症效应， 促进肿瘤的生长和侵袭； IL⁃6促进上皮细胞间质转化过程等。

2024年12月25日 · IL32 (Interleukin 32) is a Protein Coding gene. Diseases associated with IL32 include Granulomatosis With Polyangiitis and Pancreatic Cancer. Among its related pathways are Signaling by Rho GTPases and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity.

Interleukin-32 is a novel cytokine whose presence has been confirmed in most of the mammals except rodents. The IL-32 gene was identified on human chromosome 16 p13.3. The gene has eight exons and nine splice variants, namely, IL-32 α, IL-32 β, IL-32 γ, IL-32 δ, IL-32 ε, IL-32 ζ, IL-32 η, IL-32 θ, and IL-32s.

2024年4月7日 · Interleukin 32 (IL32) is a pro-inflammatory cytokine that plays a key role in promoting sterile inflammation by modulating immune responses. However, the role of IL32 in various...

Interleukin-32 (IL-32) is a novel cytokine involved in inflammation and cancer development. IL-32 gene consists of eight small exons, and IL-32 mRNA has nine alternative spliced isoforms, and was thought to be secreted because it contains an internal signal sequence and lacks a transmembrane region. …

il-32对肿瘤的发生、侵袭及迁移也有重要的影响，其作用的差异可能与il-32的亚型及复杂的肿瘤微环境差异相关。 此文旨在阐释IL-32在炎症和肿瘤中的作用及相关机制。

IL-32, a newly-discovered proinflammatory cytokine that activates the p38MAPK and NF-kappaB pathways, is an important player in innate and adaptive immune response. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and incr …