IL-34 is a novel cytokine that was identified in 2008 in a comprehensive proteomic analysis as a tissue-specific ligand of CSF-1 receptor (CSF-1R). IL-34 exists in all vertebrates including fish, amphibians, birds, and mammals, showing high conservation among species.

Interleukin 34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening of secreted proteins; chimpanzee, murine, rat and chicken interleukin 34 orthologs have also been found.

2017年9月12日 · 白细胞介素 34（interleukin-34）是 Lin 等研究人员在研究细胞与细胞之间信号交流时发现的一种新型的白细胞介素。 随后，世界各地的研究人员对这一新的白细胞介素进行了广泛的研究，逐渐发现了其特性、受体和生物学活性，以及与一些疾病的关系，如心血管疾病和自身免疫疾病. 2. 分子结构. IL-34 可由神经元、角质形成细胞和成骨细胞等分泌，其 mRNA 可在心、肝、脾、肺、脑、胸腺等多种组织和器官中表达，目前已知在脾脏中表达水平最高。 IL-34 是一种 …

2023年3月24日 · 白细胞介素 34（Interleukin-34,IL-34）可由神经元、角质形成细胞和成骨细胞等分泌，其 mRNA 可在心、肝、脾、肺、脑、胸腺等多种组织和器官中表达，目前已知在脾脏中表达水平最高。

IL-34 is an alternative ligand for the colony stimulating factor-1 receptor. Here, the authors summarize recent advances of IL-34 in macrophage development and function and its role in health and disease.

2024年12月25日 · IL34 (Interleukin 34) is a Protein Coding gene. Diseases associated with IL34 include Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1 and Tenosynovial Giant Cell Tumor. Among its related pathways are Cytokine Signaling in …

2023年11月1日 · IL-34 is a promising novel biomarker and therapeutic target for inflammatory diseases. In recent years, IL-34 has been widely discussed as a novel cytokine. IL-34 is a pro-inflammatory cytokine binding four distinct receptors, namely CSF …

IL-34 Protein, Mouse (HEK293, His) 是重组的 IL-34 蛋白，由 HEK293 表达，带有 C-His 标签。 IL-34蛋白是促进单核细胞和巨噬细胞增殖、存活和分化的重要细胞因子。 它通过促进促炎趋化因子的释放在先天免疫和炎症中发挥关键作用。 Animal-Free IL-34 Protein, Human (His) 是重组的 无动物源 IL-34 蛋白，由 E. coli 表达，带有 C-His 标签。 IL-34蛋白是促进单核细胞和巨噬细胞增殖、存活和分化的重要细胞因子。 它通过促进促炎趋化因子的释放在先天免疫反应和炎症过程 …

Local IL-34-induced macrophages augment the destruction of tubular epithelial cells and worsen AKI, while circulating IL-34 enhances the proliferation of myeloid cells and increases monocytes, thereby amplifying persistent inflammation 95.

A recent study has demonstrated that tumor cell-derived IL-34 abrogates immunotherapy efficacy through myeloid cell remodeling. On the other hand, IL-34 expression is downregulated in some brain and dermal disorders. Despite accumulating insights, our understanding of IL-34 may not be even close to its nature.