il-17还可以调节保护性th1细胞反应并增强真菌感染的免疫病理学。 在致密隐球菌感染的小鼠模型中，γδT细胞早期分泌IL-17抑制了真菌清除所需的保护性TH1细胞反应，并促进中性粒细胞相关炎症。

Until recently, T cells were divided into Th1 or Th2 cells, depending on the cytokines they produce. A third subset of IL-17-producing effector T helper cells, called Th17 cells, has now been discovered and characterized. Here, we summarize the current information on the differentiation and effector functions of the Th17 lineage.

Th17细胞是首个被确定有别于Th1/Th2模式的亚群，且基于IL-23刺激后IL-17A同型二聚体的表达。 Th17细胞生成另一个同型二聚体IL-17家族成员IL-17F，以及异质二聚体蛋白IL-17AF，IL-17AF由IL-17A的一个亚基和IL-17F的一个亚基组成。

2014年8月22日 · All known IL-17-dependent signalling events occur through ACT1, which controls TNF receptor-associated factor (TRAF)-dependent activation of downstream signalling components (for example,...

Th17细胞是首个被确定为有别于持续了几十年的原始Th1/Th2模式的亚群，最初被定义的特征是基于IL-23刺激后IL-17A同型二聚体的表达。 后来的观察发现，Th17细胞生成另一个同型二聚体IL-17家族成员——IL-17F，以及异质二聚体蛋白——IL-17AF，后者由IL-17A的一个亚基和 ...

2025年3月14日 · 1989年，Th1和Th2细胞的二分法奠定了T细胞研究的基石。 然而，2005年，董晨教授与Casey Weaver团队在《自然·免疫学》上的突破性研究，揭示了第三类T细胞亚群——Th17细胞，其以分泌IL-17为标志，彻底改写了免疫学教科书。

Th17 cells can be stimulated with the use of IL-6/transforming growth factor (TGF)-β (Ghilardi and Ouyang 2007) or IL-23p40 pathway. Main inhibitors of Th17 cells are cytokines produced by Th1 and Th2 cells, interferon (IFN)-γ and IL-4, respectively (Stumhofer et al. 2007).

GLS deficiency promoted Th1 and suppressed Th17 differentiation and may affect plasticity and terminal fates. However, GLS-deficient T cells stimulated in Th17 conditions that failed to express RORγt and IL17 did not significantly elevate IFNγ or FoxP3 (Figures 2E, 4A, and S4A).

2012年10月1日 · Interleukin-17 (IL-17) is a pro-inflammatory cytokine that contributes to the pathogenesis of several inflammatory diseases. The key IL-17 family members are IL-17A and...

2020年11月26日 · We found increased pathogenicity of Th1 cells differentiated in the presence of IL-18 underlining the importance of IL-18 for Th1 differentiation. In addition, we identified restimulation of Th17 cells in vitro, IL-17 production on the day of transfer, and number of cells transferred as influencing variables on the disease course.