Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene. [5][6] The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor.

2024年12月25日 · IL18RAP (Interleukin 18 Receptor Accessory Protein) is a Protein Coding gene. Diseases associated with IL18RAP include Crohn's Disease and Leprosy. Among its related pathways are IL-1 Family Signaling Pathways and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include signaling receptor activity.

该基因编码的蛋白质是白介素 18 (IL18) 异二聚体受体的辅助亚基，IL18 是一种参与诱导细胞介导免疫的促炎细胞因子。 该蛋白增强了 IL18 受体的 IL18 结合活性，并在 IL18 的信号传导中发挥作用。 该基因的突变与克罗恩病和炎症性肠病以及对乳糜泻和麻风病的易感性有关。 已经描述了该基因的选择性剪接转录物变体，但它们的全长性质尚不清楚。 [RefSeq 提供，2014 年 2 月]

2023年12月11日 · Several new discoveries have revived interest in the pathogenic potential and possible clinical roles of IL-18. IL-18 is an IL-1 family cytokine with potent ability to induce IFNγ production....

IL18RAP shares 65% amino acid identity with the homologous mouse protein and 25 to 27% identity with members of the IL1R family. IL18RAP is predicted to contain a 14-amino acid signal peptide, a 342-amino acid extracellular (Ig superfamily-like) segment, a single transmembrane region, and a 222-amino acid cytoplasmic domain that is 32% ...

IL18RAP is a novel predisposing gene for coeliac disease. study provides suggestive evidence for associations of SNPs in the IL1RL1 gene and adjacently located family members IL18R1 and IL18RAP with asthma and atopy in 2 independent Dutch asthma populations

2024年9月18日 · 白细胞介素IL18是IL-1细胞因子家族的成员，一种促炎细胞因子，具有诱导IFNγ产生的能力，在炎症中起重要作用。 主要参与上皮屏障修复，Th1细胞和自然杀伤（NK）细胞的免疫反应 。 IL18与质膜上的IL18受体α（Rα）和β（Rβ）链形成信号复合物，从而诱导多种炎症细胞因子。 IL18的表达分布. IL18主要表达在巨噬细胞中表达，粒细胞，库普弗细胞也有表达，除此之外，IL18在非造血细胞，例如肠上皮细胞，角质形成细胞和内皮细胞中组成性表达。 …

2025年2月8日 · The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18.

IL-18 R beta (IL-1R7), also known as IL18RAP (Interleukin 18 Receptor Accessory Protein), is a member of the IL-1 family. IL-18 R beta is the subunit of IL-18 R. IL-18 forms a signalling complex with the IL-18 receptor α (Rα) and β (Rβ) chains at the plasma membrane, which induces multiple inflammatory cytokines [1] .

这个基因编码的蛋白质是白细胞介素18（IL18）异源二聚受体的一个辅助亚基，IL18是一种参与诱导细胞介导免疫的促炎细胞因子。 这个蛋白质增强了IL18受体的IL18结合活性，并在IL18的信号传导中发挥作用。 这个基因的突变与克罗恩病和炎症性肠病、以及小麦过敏症和麻疯病的易感性有关。 这个基因的可变剪接转录变异已经被描述过，但是它们的全长性质尚不清楚。 [由RefSeq，2014年2月提供] Dir./Indir. 该模块正在开发中，请耐心等待我们的数据更新。 …