Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene. [5] The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21).

其中， 白介素IL21 （Interleukin 21）是主要的免疫调节剂之一，通过影响多种免疫细胞来调节各种免疫应答。 百奥动物开发了 B-hIL21R mice，为临床前药效评估提供了优质模型。 关于靶点IL21. IL21R编码白细胞介素21 (IL21)的细胞因子受体。 它属于I型细胞因子受体，并已被证明与 共同γ链 （γc）形成异二聚体受体复合物。 γc亚基也是IL2、IL4、IL7、IL9和IL15的共同受体。 该受体转导IL21的促生长信号，对T细胞、B细胞和自然杀伤 (NK)细胞的增殖和分化具有重要意义 …

2024年12月25日 · IL21R (Interleukin 21 Receptor) is a Protein Coding gene. Diseases associated with IL21R include Immunodeficiency 56 and Ige Responsiveness, Atopic. Among its related pathways are Cytokine Signaling in Immune system and Th17 Differentiation. Gene Ontology (GO) annotations related to this gene include interleukin-21 receptor activity.

白介素-21受体（英語： Interleukin-21 receptor ，缩写IL21R）也称为分化簇360（CD360，cluster of differentiation 360）是一种细胞表面蛋白质，由人类基因 IL21R 编码 [6] ，能与白细胞介素-21（IL-21）结合。

Its private receptor, IL-21R, has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathway upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells.

In this review, we assess the current knowledge regarding CD4 T cell-derived IL-21 and IL21R signaling within CD8 T cells and evaluate what implications it has within several autoimmune diseases including systemic lupus erythematous, rheumatoid arthritis, juvenile idiopathic arthritis, type 1 diabetes mellitus, psoriasis, Sjögren’s syndrome, vit...

2024年12月9日 · The IL21/IL21R axis reduced the growth and invasion of NSCLC cells via inhibiting Wnt/betacatenin signaling and PDL1 expression. The present results may provide a novel molecular target for NSCLC diagnosis and therapy.

2025年2月8日 · IL21R hypomethylation as a biomarker for distinguishing benign and malignant breast tumours. Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA[+] B cells.

2024年9月2日 · IL-21受体（IL-21R）是一个由IL21Rα蛋白和γ链组成的异源二聚体。 IL-21和其受体结合会形成一个三元复合物，IL-21通过其A和C螺旋与IL-21R的D1结构域结合。 （数据来源 Abhiraman GC, et al. Cell Rep. 2023） IL-21的信号通路和调控： IL-21与IL21R受体复合物结合后会激活下游信号通路，致Janus激酶1（JAK1）和JAK3的活化，从而允许信号转导和转录激活因子（STAT）蛋白的募集和磷酸化（主要是STAT3，也有STAT1和STAT5）。 这些STAT蛋白二 …

2014年4月22日 · Interleukin-21 (IL-21) binding stabilizes the complex between the IL-21 receptor (IL-21R) and the common cytokine-γ chain, γ c, leading to the activation of Janus kinase 1...