2024年12月25日 · IL2RB (Interleukin 2 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL2RB include Immunodeficiency 63 With Lymphoproliferation And Autoimmunity and Ichthyosis. Among its related pathways are TGF-Beta Pathway and MIF Mediated Glucocorticoid Regulation.

Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene. [5] . Also known as CD122; IL15RB; P70-75. [5] The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2.

白介素-2受体β亚基 （Interleukin-2 receptor subunit beta，缩写 IL2RB）也称为“白介素-15受体β亚基”（IL15RB）、P70-75、 分化簇122 （CD122，cluster of differentiation 122）是一种细胞表面蛋白质，由人类基因 IL2RB 编码 [7]，能与 白介素-2受体α亚基 （CD25）、 γ亚基 （CD132）共同组成 白介素-2受体 [8]，或与 白介素-15受体α亚基 （CD215）、 γ亚基 （CD132）共同组成 白介素-15受体 [9]。 ^ 與IL2RB相關的疾病；在維基數據上查看/編輯參考.

IL-2是第一个被克隆的细胞白介素因子，也是首个被批准用于肿瘤治疗的因子，早期被命名为T细胞生长因子（TCGF），属于Ⅰ型细胞因子家族成员。 IL-2主要由CD4+ T细胞产生。 IL2基因表达的调控涉及多种转录因子，包括活化T细胞家族成员的核因子（NFAT）、激活蛋白1（AP-1）、核因子Κb（NF-κB）、八聚体结合蛋白1（POU2F1）、高迁移率族蛋白（HMGA1）、FOXP3蛋白。 IL-2主要激活三种信号通路：JAK-STAT、ERK和PI3K。 IL-2受体是由α、β、γ三条链组成的异 …

2024年9月13日 · il2rb蛋白是il-2受体复合体的重要组成部分，其结构和功能对免疫系统的正常运 作至关重要。 通过研究IL2RB的结构特点和调控机制，能够更好地理解其在免疫调

IL2RB affects Th1/Th2 and Th17 responses of peripheral blood mononuclear cells from septic patients. Upregulated Expression of IL2RB Causes Disorder of Immune Microenvironment in Patients with Kawasaki Disease. Interleukin 2 receptor subunit beta as a novel hub gene plays a potential role in the immune microenvironment of abdominal aortic ...

该基因编码的蛋白质代表 β 亚基，是一种 I 型膜蛋白。 替代启动子的使用导致编码相同蛋白质的多个转录变体。 该蛋白质主要在造血系统中表达。 上游长末端重复序列 (LTR) 中替代启动子的某些变体的使用导致胎盘特异性表达。 [RefSeq 提供，2016 年 9 月] The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2.

A novel homozygous mutation in human IL2RB results in decreased IL-2Rβ protein expression and dysregulated IL-2/15 signaling. This hypomorphic mutation leads to decreased regulatory T cell frequency and an abnormal NK cell compartment, with clinical ...

2018年8月8日 · With the cloning of IL-2 receptor α-chain (IL-2Rα, encoded by IL2RA; also known as CD25) 5, 6 and then IL-2Rβ (encoded by IL2RB; also known as CD122) 7, it became clear that IL-2Rα 5 lacks a...

2019年7月9日 · The IL2RB gene encodes the beta subunit of the interleukin-2 (IL2) receptor, which transmits signals from the cytokines IL2 (147680) and IL15 (600554). IL2RB shows constitutive or induced expression on various types of immune cells, including CD4+ T regulatory cells, CD4+ and CD8+ T cells, B cells, and NK cells (summary by Zhang et al., 2019).