
Interleukin 4 - Wikipedia
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in …
白介素家族信号通路及功能概述 - 翌圣生物
目前发现了38种白细胞介素,分别命名为IL-1—IL-38,其受体可分为I型、II型和其他型。 其中II型白细胞介素受体包括白细胞介素-10、20、22、28受体,其他型包括白介素-1、8受体,其余 …
Remodeling of Il4-Il13-Il5 locus underlies selective gene expression
2024年11月20日 · Physical proximities among REs were coordinately remodeled in three-dimensional space after cell activation, leading to divergent compartmentalization of Il4, Il13 …
白细胞介素-4 - 维基百科,自由的百科全书
白细胞介素-4 (白介素-4, Interleukin-4, IL-4)是II型 辅助T细胞 (Th2细胞)分泌的细胞因子。 白细胞介素-4的生物作用,包括刺激活化 B细胞 和 T细胞 增殖、 CD4+T细胞分化成II型辅助T细 …
IL3-Driven T Cell-Basophil Crosstalk Enhances Antitumor Immunity
2024年7月2日 · Introducing IL3-activated basophils retarded tumor progression, whereas basophil depletion diminished the effectiveness of IL3 supplementation. Furthermore, IL3 prompted …
研究报告 | 免疫治疗中白介素家族的研发现状 - 健康界
2021年7月30日 · 各类白介素主要参与肿瘤、自身免疫和炎症等疾病的信号通路,目前机制研究较为透彻的白介素包括il1、il2、il3、il4、il5、il6、il10、il11、il15、il17等,以这些白介素为靶 …
Evolutionary divergence and functions of the human interleukin (IL ...
Along with IL13, IL4 regulates immunoglobulin class switching in B cells and mast cell recruitment . IL3, IL4, IL5 and CSF2 facilitate granulocyte maturation and therefore also play an important …
文献解读:IL3介导细胞毒性T细胞-嗜碱性粒细胞互作增强抗肿瘤免 …
2024年8月15日 · 山东大学基础医学院魏健研究员在免疫学领域期刊《Cancer Immunology Research》发表最新研究成果“IL3-Driven T Cell–Basophil Crosstalk Enhances Antitumor …
IL-3 synergizes with basophil-derived IL-4 and IL-13 to promote …
A basophil-monocyte co-culture model revealed that IL-3 and basophil-derived IL-4 and IL-13 induced monocyte production of CCL17, a marker of alternative activation. Critically, IL-3 and …
Recent advances in understanding the role of IL-4 signaling
GATA3 directly activates Il5 transcription 45; it also plays an important role in chromatin remodeling at the Il4/Il13 cytokine locus during Th2 cell differentiation 46–48. In addition, the …