Oncostatin M and interleukin-31: Cytokines, receptors, signal ...
2015年10月1日 · Animal models investigating IL-31 physiology and recent findings for IL-31 in human disease. Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to …
【靶点新势力】炎症导向型IL-31，前路漫漫亦灿灿 - 知乎
IL-31通过由 OSMR 和IL-31RA组成的异二聚体受体复合物进行信号转导。 其中IL-31RA具有单个跨膜结构域，该细胞内结构域具有富含脯氨酸的基序，介导 JAK家族激酶 的下级传递，因此对 …
Structures and biological functions of IL-31 and IL-31 receptors
IL-31RA is a novel type I cytokine receptor that mediates IL-31 signaling when coupled with OSMR . The IL-31R was discovered independently by three research groups using …
白细胞介素-31（IL-31） - 丁香通研选
2017年9月4日 · IL-31 其功能受体是由 IL-31R 和抑瘤素 M 受体（OSMR，oncostatinM receptor）两个亚基组成的异源二聚体复合物。 有研究显示，来自气道过敏症的动物模型病变 …
Interleukin-31, Interleukin-31RA, and OSMR Expression Levels …
2018年8月3日 · Immunohistochemistry results were semi-quantitatively evaluated for IL-31, IL-31RA, and OSMR. By hematoxylin and eosin staining, epidermal and dermal thickness were …
炎症中的“瘙痒”细胞因子IL31
2024年10月17日 · Nemolizumab是第一个被批准上市的靶向IL31RA的单克隆抗体，它通过与IL31受体α相结合，可以阻断IL31的信号通路。 由Chugai Pharmaceutical开发用于治疗结节性 …
Oncostatin M and interleukin-31: Cytokines, receptors, signal ...
Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of …
Signaling by IL-31 and functional consequences - ScienceDirect
2012年6月1日 · IL-31 stimulation inhibits cell proliferation of HCT116 cells, comparable to the effects in lung epithelial cells, and increases cell migration. Induction of differentiation in …
Canine interleukin-31 binds directly to OSMRβ with higher binding ...
Interleukin-31 (IL-31) is a pro-inflammatory cytokine involved in skin inflammation and tumor progression. The IL-31 signaling cascade is initiated by its binding to two receptors, IL-31 …
Interleukin-31 and Oncostatin-M Mediate Distinct ... - ScienceDirect
2007年2月2日 · The OSM receptor (OSMR) signals through activation of STAT and mitogen-activated protein kinase pathways to induce genes encoding differentiated cell functions, …