2015年10月1日 · Animal models investigating IL-31 physiology and recent findings for IL-31 in human disease. Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ).

IL-31通过由 OSMR 和IL-31RA组成的异二聚体受体复合物进行信号转导。 其中IL-31RA具有单个跨膜结构域，该细胞内结构域具有富含脯氨酸的基序，介导 JAK家族激酶 的下级传递，因此对传播信号至关重要。 IL-31主要通过三条途径进行信号转导：磷脂酰肌醇30-激酶/蛋白激酶（PI3K/AKT）通路、Janus激酶/信号转换器和转录激活因子（JAK/STAT）通路及丝裂原激活的蛋白激酶（MAPK）通路。 目前认为IL-31具有诱导促炎细胞因子的释放、调节细胞增殖及免疫 …

IL-31RA is a novel type I cytokine receptor that mediates IL-31 signaling when coupled with OSMR . The IL-31R was discovered independently by three research groups using bioinformatic tools to search gene databases for novel cytokine receptors that share the conserved structural motifs of a type I cytokine receptor.

2017年9月4日 · IL-31 其功能受体是由 IL-31R 和抑瘤素 M 受体（OSMR，oncostatinM receptor）两个亚基组成的异源二聚体复合物。 有研究显示，来自气道过敏症的动物模型病变组织中的 IL-31 受体表达增加。

2018年8月3日 · Immunohistochemistry results were semi-quantitatively evaluated for IL-31, IL-31RA, and OSMR. By hematoxylin and eosin staining, epidermal and dermal thickness were assessed with a microscope and digital camera.

2024年10月17日 · Nemolizumab是第一个被批准上市的靶向IL31RA的单克隆抗体，它通过与IL31受体α相结合，可以阻断IL31的信号通路。 由Chugai Pharmaceutical开发用于治疗结节性痒疹，特应性皮炎，

Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon bindi …

2012年6月1日 · IL-31 stimulation inhibits cell proliferation of HCT116 cells, comparable to the effects in lung epithelial cells, and increases cell migration. Induction of differentiation in HCT116 cells, using sodium butyrate, increases the expression of IL31RA, OSMR, and IL31.

Interleukin-31 (IL-31) is a pro-inflammatory cytokine involved in skin inflammation and tumor progression. The IL-31 signaling cascade is initiated by its binding to two receptors, IL-31 receptor alpha (IL-31RA) and oncostatin M receptor subunit beta (OSMRβ).

2007年2月2日 · The OSM receptor (OSMR) signals through activation of STAT and mitogen-activated protein kinase pathways to induce genes encoding differentiated cell functions, reduce cell-cell interaction, and suppress cell proliferation.