DoD IL4 overview. The Defense Information Systems Agency (DISA) is an agency of the US Department of Defense (DoD) that is responsible for developing and maintaining the DoD Cloud Computing Security Requirements Guide (SRG). The Cloud Computing SRG defines the baseline security requirements used by DoD to assess the security posture of a cloud ...

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in a positive feedback loop.

2024年12月25日 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation.

STAT6 is so vital for the actions of IL-4 that Stat6-deficient mice phenocopy many of the defects observed with Il4- or Il4ra-deficient mice (e.g., related to Th2 differentiation and Ig class switch).

IL4: Protects controlled unclassified information (CUI) that has a low to moderate impact on national security if compromised. IL5: Adds stricter controls for CUI and data in unclassified national security systems, requiring moderate confidentiality and moderate integrity.

2021年9月7日 · Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this cytokine acts on more than a dozen different target cells spanning the innate and adaptive immune systems and is produced by multiple different cellular sources.

2003年7月1日 · Acute expression of the IL4 gene by differentiated T H 2 cells is regulated by many positive and negative inducible transcription factors, such as nuclear factor of activated T cells (NFAT ...

2024年12月10日 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation.

2012年11月1日 · IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning.

Interleukin-4 (IL4) is a growth factor for both B and T lymphocytes. - High levels of IL4Rs have been observed on tumors derived from such cells. - IL4Rs are also overexpressed on activated T lymphocytes, which mediate autoimmune disorders.