Targeted deletion of the TSLP receptor reveals cellular ... - Nature
2020年2月17日 · After sensitization with OVA + MC903, the frequency of GATA3 + CD4 + T cells and type 2 cytokine secretion induced by OVA re-stimulation were significantly suppressed in …
Skin microbe-dependent TSLP-ILC2 priming axis in early life is co …
2024年2月14日 · Previous studies have shown that topical application of MC903, a low-calcemic analog of vitamin D3 (calcipotriol) to mouse skin induces an AD-like dermatitis model …
RORα-expressing T regulatory cells restrain allergic skin ... - Science
MC903-mediated eosinophilia was attenuated in Tnfrsf25 −/− mice , demonstrating a role for TL1A in MC903-driven allergic skin inflammation. Intradermal injection of TL1A into ear skin …
基于药物MOA诱导的过敏小鼠模型选择之特应性皮炎 - 知乎
MC903即 卡泊三醇，是一种维生素D3的低钙类似物，广泛用于治疗银屑病。 研究发现，局部使用MC903可激发小鼠上皮角质细胞高表达TSLP，促进CD4+T细胞向Th2细胞分化及激活并释放 …
Intelectin contributes to allergen-induced IL-25, IL-33, and
2017年2月22日 · We investigated the role of Itln in the pathogenesis of asthma models induced by OVA or house dust mite (HDM), and in AD models induced by vitamin D3 analog …
Homeostatic Control of Sebaceous Glands by Innate Lymphoid …
Here, we uncovered spatial compartmentalization of skin-resident innate lymphoid cells (ILCs) and modulation of sebaceous glands by a subset of RORγt + ILCs residing within hair follicles …
Genomic control of inflammation in experimental atopic dermatitis …
2022年11月7日 · MC903, applied topically to mouse ears, induces the characteristic signs of AD consisting of swelling, and T H2 type inflammation manifested in a dermal infiltrate. These …
Skin-Resident Innate Lymphoid Cells – Cutaneous Innate …
ILC2s are enriched in lesional skin of patients with atopic dermatitis and promote MC903-induced atopic inflammation in mice, likely via the production of type 2 cytokines such as interleukin …
肠道菌群代谢产物IAID对特应性皮炎小鼠模型的作用-论文-万方医 …
目的：：确定肠道菌群代谢产物吲哚－3－甲醛 ( IAID,indole－3－carboxaldehyde)在特应性皮炎 ( AD)小鼠模型中的作用。 方法：将C57小鼠随机分为对照组、模型组和IAID组。 小鼠双耳外涂 …
TSLP elicits IL-33–independent innate lymphoid cell responses to ...
In this study, we employed the murine model of MC903-induced AD-like disease to recapitulate human AD. MC903-treated mice were previously reported to exhibit enhanced susceptibility to …
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