Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others. Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V (D)J recombination [citation needed].

2024年12月25日 · IL7R (Interleukin 7 Receptor) is a Protein Coding gene. Diseases associated with IL7R include Immunodeficiency 104, Severe Combined and T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency. Among its related pathways are TGF-Beta Pathway and Akt Signaling.

IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well as in B cell maturation through the activation of the IL-7 receptor (IL-7R). IL-7 is closely associated with tumor development and has been used in cancer clinical research and therapy.

Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (C luster of D ifferentiation 127) is a protein that in humans is encoded by the IL7R gene. [5][6] IL7R-α is a type I cytokine receptor and is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors. ^ "Human PubMed Reference:".

2019年11月19日 · Here we discuss the central role of IL-7 and IL-7R in the lymphoid system and highlight the impact of their deregulation, placing a particular emphasis on their ‘dark side’ as promoters of...

Interleukin-7 receptor α (IL7R) is required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined immune deficiency. Here, we describe somatic gain-of-function mutations in IL7R in …

The IL7R gene provides instructions for making a protein called interleukin 7 (IL-7) receptor alpha chain. This protein is one piece of both the IL-7 receptor and the thymic stromal lymphopoietin (TSLP) receptor. These receptors are embedded in the cell membrane of immune system cells.

Expression of IL-7 and IL-7R in RA monocytes is linked to disease activity score and TNF transcription. TNF stimulation can modulate IL-7 secretion and IL-7R frequency in myeloid cells, however, only IL-7R transcription levels are downregulated in anti-TNF responsive patients.

2025年2月11日 · Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer.

2019年10月8日 · Here we characterize genetic regulation of IL7R at the protein level in healthy individuals, and find that monocyte surface and soluble IL7R (sIL7R) are markedly induced by lipopolysaccharide.