Integrin-linked kinase (ILK), which is an ankyrin repeat-containing serine/threonine protein kinase, interacts with integrin β1 and the β3 cytoplasmic domain and phosphorylates integrin β1. ILK has multiple functions in cells, such as ...

Our results demonstrated that ILK promoted proliferation and suppressed apoptosis via repressing phosphorylations of the JNK signal pathway in human retinoblastoma cells. This might provide a potential therapeutic target in the treatment of this deadly disease.

2009年6月1日 · The authors provide compelling evidence of the Jekyll and Hyde nature of ILK: its tumor-suppressive function in ERMS and its oncogenic role in ARMS. A key issue, however, is the mechanism by which ILK targets JNK activity. How does ILK function to suppress JNK activation in ERMS, yet activate JNK in ARMS?

2009年6月1日 · We found that ILK was pro-oncogenic in ARMS and tumor suppressive in ERMS in vitro and in vivo. The tumor-suppressive function of ILK relied on the regulation of JNK1: depletion of ILK led to activation of JNK/c-Jun signaling in ERMS cells …

Integrin linked kinase (ILK) is an intracellular protein whose main function is to connect integrins to the cytoskeleton. Different domains of ILK interact with different proteins. For example, the C-terminal region interacts with several actin binding adapter proteins, while ANK repeats bind to PINCH protein and ILKAP.

2009年12月15日 · This review discusses the complex roles of ILK in tumorigenesis, and offers arguments to harness ILK and JNK signaling as novel targets for anti-cancer therapy.

The ILK, ERK1/2 and p38 signals are significantly up-regulated by MNT, whereas the JNK activity is undetectable by Western blot. The MG63 cell morphology, proliferation and differentiation are studied in the absence and presence of the MAPK subgroup inhibitors to confirm their roles in cell functions on the Ti surface.

该基因编码一种具有激酶样结构域和四个锚蛋白样重复序列的蛋白质。 编码的蛋白质在细胞膜上与 β 整合素的细胞质结构域结合，在此处调节整合素介导的信号转导。 这种蛋白质的活性在上皮到间充质的转化中很重要，并且这种基因的过度表达与肿瘤生长和转移有关。 可变剪接导致多个转录本变体。 [RefSeq 提供，2013 年 6 月] This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats.

2005年12月21日 · Integrin-linked kinase (ILK), PINCH and parvin form a ternary complex (the IPP complex) that binds to ECM-ligated integrins. This complex regulates signalling pathways and...

2009年5月26日 · The authors provide compelling evidence of the Jekyll and Hyde nature of ILK: its tumor-suppressive function in ERMS and its oncogenic role in ARMS. A key issue, however, is the mechanism by which ILK targets JNK activity. How does ILK function to suppress JNK activation in ERMS, yet activate JNK in ARMS?