Imipenem (trade name Primaxin among others) is a synthetic β-lactam antibiotic belonging to the carbapenems chemical class. developed by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in the mid-1970s. [1] .

亚胺培南 （INN：imipenem）是一种半合成的 碳青霉烯类 抗生素， 属于 β-内酰胺类。 亚胺培南主要抑制细菌细胞壁合成，抗菌活性极高，对革兰氏阴性菌、阳性菌、厌氧菌都有抗菌作用，也可用于耐多药结核菌 [1]。 同其他碳青霉烯类抗生素类似，亚胺培南对许多多重耐药革兰氏阴性菌产生的 β-内酰胺酶 具有高度抗性 [2]，因此在治疗耐药菌导致的感染中发挥关键作用 [3]。 该药于20世纪70年代中期由 默沙东 开发 [4]。 默沙东于20世纪70年代早期通过长时间的筛选从卡特 …

2023年9月7日 · Imipenem and cilastatin is an antibiotic that is used in adults and children to treat bacterial infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. Imipenem and cilastatin may also be used for purposes not listed in this medication guide.

Imipenem is a carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial …

亚胺培南，是一种医学药品，临床主要用于革兰阳性菌、阴性菌、厌氧菌所致的呼吸道感染、胆道感染、泌尿系统和腹腔感染、皮肤软组织、骨和关节、妇科感染等。

Imipenem/cilastatin/relebactam, a relatively newer antibiotic, combines imipenem, cilastatin, and relebactam. Imipenem is a bactericidal carbapenem known for binding and inhibiting penicillin-binding proteins (PBP 1 B and PBP 2) in Enterobacteriaceae and P.-aeruginosa inhibits bacterial cell wall synthesis [22, 23].

Imipenem is the first of a new class of β-lactam antibiotics, the carbapenems, to be released for clinical use. It has the broadest antibacterial activity of all antibiotics available for systemic use in humans.

2017年1月17日 · Imipenem is a broad spectrum carbapenem antibiotic which is used for severe bacterial infections caused by susceptible organisms. Because imipenem is rapidly inactivated by renal dehydropeptidase I (DHP-1), it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem.

Imipenem is a beta-lactam antibiotic belongings to the subgroup of carbapenems. Imipenem is active against aerobic and anaerobic Gram positive as well as Gram negative bacteria including Pseudomonas aeruginosa and the Enterococcus. It exerts a …

Imipenem is a semi-synthetic derivative of thienamycin, a β-lactam produced by Streptomyces cattleya, with very broad in vitro activity both against aerobic and anaerobic enteric bacteria, including most β-lactamase-producing strains.