2025年1月28日 · The CLL international prognostic index (CLL-IPI) integrates genetic, biological, and clinical variables to identify distinct risk groups of patients with CLL. The CLL-IPI retains its significance in the era of targeted agents, but the overall prognosis of CLL patients with high-risk stages has improved.

Abstract Disease overview: Chronic lymphocytic leukemia (CLL) is one of the most frequent types of leukemia. It typically occurs in elderly patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alter- ations that interfere with the regulation of proliferation and of apoptosis in clonal

We identify 44 recurrently mutated genes and 11 recurrent somatic copy number variations through whole-exome sequencing of 538 chronic lymphocytic leukemia (CLL) and matched germline DNA samples, 278 of which were collected in a prospective clinical trial.

2019年8月9日 · Genome-wide association studies have provided evidence for inherited genetic predisposition to chronic lymphocytic leukemia (CLL). To gain insight into the mechanisms underlying CLL risk we...

Inferring CNV from Single-Cell RNA-Seq. Contribute to broadinstitute/infercnv development by creating an account on GitHub.

2024年5月4日 · Split the CLL dataset into healthy and aggressive stimulated and unstimulated dataset.

2023年1月9日 · Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics underlying...

2021年12月12日 · In this review, we describe the application of mouse models to the studies of CLL pathogenesis and disease transformation from an indolent to a high-grade malignancy (ie, Richter syndrome [RS]) and treatment, with a focus on newly developed genetically inspired mouse lines modeling recurrent CLL genetic events.

2024年11月5日 · We applied our framework to RNA sequencing data obtained after ex-vivo perturbation with ten different small-molecule inhibitors in primary tumor cells from 108 chronic lymphocytic leukemia (CLL) patients, yielding 1010 transcriptional drug response profiles (Do et al., ASH2023 abstract 4633).

2018年9月1日 · Chronic lymphocytic Leukaemia (CLL) is characterized by significant clinical and biological heterogeneity. Despite recent advances in therapy, CLL remains largely incurable.