Activin is a dimer composed of two identical or very similar beta subunits. Inhibin is also a dimer wherein the first component is a beta subunit similar or identical to the beta subunit in activin.

inhibin, hormone secreted by the granulosa cells in the ovaries of women that acts primarily to inhibit the secretion of follicle-stimulating hormone by the anterior pituitary gland.

First identified as regulators of follicle-stimulating hormone secretion and erythropoiesis, activin and inhibin are involved in diverse processes during development and in terminally differentiated cells and tissues.

Inhibin is a 32-kD dimeric (α and β subunits) glycoprotein produced by ovarian granulosa cells, testicular Sertoli cells, and, to a lesser degree, testicular Leydig cells. It inhibits the release of follicle-stimulating hormone from the pituitary-inhibiting folliculogenesis.

2022年12月15日 · Inhibin is an important hormone for male and female reproductive health. It is involved in the development of reproductive organs, fertility, and pregnancy. It also serves as a diagnostic marker for a variety of body functions and conditions.

Inhibin has been defined as a gonadal hormone that exerts a specific negative feedback action on the secretion of FSH from the gonadotropic cells of the pituitary gland. The existence of inhibin was postulated as early as 1923 (250).

Ninety years later, what we know about inhibin stretches far beyond its well-established capacity to inhibit activin signaling and suppress pituitary FSH production. Inhibin is one of the major reproductive hormones involved in the regulation of folliculogenesis and steroidogenesis.