FSH stimulates the secretion of inhibin from the granulosa cells of the ovarian follicles in the ovaries. In turn, inhibin suppresses FSH. Inhibin B reaches a peak in the early- to mid-follicular phase, and a second peak at ovulation. Inhibin A reaches its peak in the mid-luteal phase.

This test can aid in the diagnosis of granulosa cell tumors and mucinous epithelial ovarian tumors and helps with monitoring of patients with granulosa cell tumors and epithelial mucinous-type tumors of the ovary known to over-express inhibin B.

2021年1月21日 · Inhibin A and inhibin B tumor marker tests measure these blood hormone levels to help detect a rare ovarian granulosa cell tumor.

Inhibin B is a dimer of an alpha and a betaB subunit. It is produced exclusively by the testis, predominantly by the Sertoli cells in the prepubertal testis, while the site of production in the adult is still controversial. Inhibin B controls FSH secretion via a negative feedback mechanism.

Inhibin B is a peptide hormone that is produced primarily by growing antral follicles that are responsive to FSH. As the follicle continues to grow and become dominant, inhibin B secretion declines. As the growing pool of antral follicles decreases during aging, levels of …

Inhibins are heterodimeric protein hormones secreted by granulosa cells of the ovary and Sertoli cells of the testis. Inhibins selectively suppress secretion of pituitary follicle-stimulating hormone (FSH) and have local paracrine actions in the gonads.

We evaluated the relationship between inhibin B and classic ovarian reserve and function markers. The potency of inhibin B in predicting AFC <5-7 was also estimated and compared with FSH. The nomogram showed that serum levels of inhibin B rapidly decreased after the age of 40.

The ultra-sensitive inhibin B enzyme-linked immunosorbent assay is a quantitative three-step sandwich type immunoassay. Sample is incubated in wells that have been coated with inhibin B antibody. After incubation and washing, the wells are incubated with biotinylated inhibin B …

The granulosa cells produce estrogen and inhibins, driven by pituitary FSH, with inhibin B the major circulating form. FSH expression is ultimately repressed by circulating inhibin B from ovarian follicles in a negative feedback loop.

2022年4月27日 · Inhibins are heterodimeric protein hormones secreted by granulosa cells of the ovary in females and Sertoli cells of the testis in males. Inhibins selectively suppress the secretion of pituitary follicle-stimulating hormone (FSH).