The present study suggests that INSR-mediated signaling is involved in the regulation of functional protein expression at the BBB and contributes to the maintenance of BBB function. Changes in the expressions of amyloid-β peptide-related proteins may contribute to the development of cerebral amyloid …

受体介导的跨细胞转运 (RMT)和 载体介导的转运 (CMT)是BBB的主要内源性转运系统。 底物选择性CMT负责运送小分子营养物质，包括葡萄糖、氨基酸、激素、离子和维生素等。 RMT通过配体-受体复合体的囊泡递送更大的分子，如转铁蛋白、胰岛素、TNF-α和表皮生长因子。 因此，RMT是研究最多的将蛋白质和抗体输送到大脑的方法。 本文就将蛋白质和抗体输送到大脑的RMT方法以及需要考虑的关键因素做一个简单介绍，以希望对未来的针对脑疾病的药物设计做一个参考。 …

2022年8月16日 · Critical functions of the blood–brain barrier (BBB), including cerebral blood flow, energy metabolism, and immunomodulation, are regulated by insulin signaling pathways....

2021年11月22日 · The insulin receptor (INSR) mediates insulin signaling to modulate cellular functions. Although INSR is expressed at the blood–brain barrier (BBB), its role in the modulation of BBB function is poorly understood. Therefore, in this study, we aimed to analyze the effect of INSR knockdown on the expression levels of functional proteins at the BBB.

The blood-brain barrier (BBB) predominantly regulates insulin transport into and levels within the brain. The BBB is also an important site of insulin binding and mediator of insulin receptor (INSR) signaling. The insulin transporter is separate from the …

Anti-InsR-based BBB-crossing carriers have been studied to deliver enzymes or recombinant functional proteins and therapeutic antibodies. In each category, we discuss representative examples of distinct designs and the effects of the different configurations on efficacy.

2024年1月1日 · The blood–brain barrier (BBB) predominantly regulates insulin transport into and levels within the brain. The BBB is also an important site of insulin binding and mediator of insulin receptor (INSR) signaling. The insulin transporter is separate from the INSR, highlighting the important, unique role of each protein in this structure.

2017年7月1日 · INSR targeted antibody and therapeutic protein fusions have shown great potential in non-human primates for treating mucopolysaccharidosis type I (MPS-I) and Alzheimer's disease, and also in brain delivery of GDNF, TNFR, erythropoietin and paraoxonase-1 (Lajoie and Shusta, 2015).

2016年1月6日 · We first evaluated two commonly studied RMT targets, low-density lipoprotein receptor-related protein 1 (Lrp1) and insulin receptor (InsR), for their ability to deliver antibodies into mouse brains. Antibodies against murine Lrp1 …

2023年12月25日 · The insulin receptor (INSR) consists in 2 insulin-binding extracellular α chains, either short (INSRα-A) or long (INSRα-B) isoforms, as well as 2 intracellular β-chains (INSRβ) containing auto-phosphorylation sites. The aim of the present study was to better understand the role of INSR located on the BBB in AD. Method