Monoclonal Antibody for studying InsR-alpha. Validated for WB. Available in 2 sizes. Highly specific and rigorously validated in-house, Insulin Receptor α (D3U7I) Rabbit Monoclonal Antibody (CST #74118) is ready to ship.

2024年12月25日 · INSR (Insulin Receptor) is a Protein Coding gene. Diseases associated with INSR include Donohue Syndrome and Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities. Among its related pathways are GPCR Pathway and ERK Signaling.

Insulin (InsR) and insulin-like growth factor-1 (IGF1R) receptors mediate the metabolic and growth-promoting actions of insulin and IGF1/IGF2, respectively. Evidence accumulated in recent years indicates that, in addition to their typical ...

2019年11月23日 · Insulin and insulin-like growth factor-1 (IGF1) have important roles in breast cancer development. The recent identification of nuclear insulin (INSR) and IGF1 (IGF1R) receptors provides a novel paradigm in the area of signal transduction.

2023年10月26日 · Insulin resistance is associated with many pathological conditions, and an in-depth understanding of the mechanisms involved is necessary to improve insulin sensitivity. Here, we show that...

Although the insulin receptor (INSR) and IGF1 receptor (IGF1R) share the vast majority of their downstream cytoplasmic mediators, most evidence is consistent with the notion that INSR activation (mainly by insulin) leads primarily to metabolic activities, whereas IGF1R activation (mainly by IGF1 or IGF2) leads to proliferative and ...

Structurally and functionally related receptors to the INSR in mammalian organisms are the insulin‐like growth factor 1 receptor (IGF1R) and the insulin receptor‐related receptor (INSRR). Although the function and signal transduction of the IGF1R and the INSRR resembles that of the INSR, major differences appear in the tissue distribution ...

胰岛素或其他配体结合到这个受体上，激活胰岛素信号通路，该通路调节葡萄糖的摄取和释放，以及碳水化合物的合成和储存，脂质和蛋白质。 这个基因中的突变导致了遗传性严重胰岛素抵抗综合征，包括A型胰岛素抵抗综合征、Donohue综合征和Rabson-Mendenhall综合征。 可变剪接产生了多种转录变异体。 [RefSeq，2015年10月提供] Dir./Indir. The DNA sequence and biology of human chromosome 19. Structure of the insulin receptor ectodomain reveals a folded-over …

2019年11月29日 · Our recent analysis of the transcriptional controls affecting expression of the Drosophila insulin receptor gene indicates that a remarkable amount of DNA is dedicated to encoding sophisticated feedback and feed forward signals.

2021年4月2日 · Co-transfection experiments in breast cancer cell lines harboring specific disruptions of either the IGF1R or InsR allowed us to investigate the impact of nuclear InsR on InsR gene expression . Studies provided evidence that InsR-A …