2025年1月20日 · Itch is a unique sensation that is mediated by specialized neurons that innervate the skin. In this primer, we will discuss recent advancements that define the molecules and …

2021年1月14日 · Instead, a previously unrecognized basophil-leukotriene (LT) axis emerges as critical for acute itch flares. By probing fundamental itch mechanisms, our study highlights a …

In this review, we will look at the cell biology of itch, with an emphasis on the receptors, cell types, and pruriceptors that are involved in the processing of itch, focusing on the periphery and how …

Itch is a unique sensory experience that is encoded by genetically distinguishable neurons both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …

2021年1月21日 · Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and noxious stimuli from the skin. However, in organ failure, cancer, and chronic …

In this review we focus on the molecules, cells and circuits in the peripheral and central nervous systems that drive acute and chronic itch transmission. Understanding the itch circuitry is …

2024年10月18日 · When itchy skin becomes severe or lasts for more than six weeks, it has deleterious effects on both quality of life and productivity. Despite decades of research, the …

2024年9月24日 · Using cell type-specific manipulations, the opposing functions of ACC glutamatergic and GABAergic neurons in regulating acute itching are demonstrated. …

为同时模拟特应性皮炎的慢性瘙痒和与过敏原有关的Acute Itch Flare，在经典特应性皮炎小鼠模型基础上，Kim实验室创制了一种新的动物模型。 首先利用 MC903 （一种卡波三醇类似物）涂 …

Here we review what is known about the cells, molecules, and circuits involved in itch and highlight key questions that remain to be answered. Keywords: Itch, pain, DRG neurons, skin, …