Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. [5][6] ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by …

2024年12月25日 · ITGA3 (Integrin Subunit Alpha 3) is a Protein Coding gene. Diseases associated with ITGA3 include Epidermolysis Bullosa, Junctional 7, With Interstitial Lung Disease And Nephrotic Syndrome and Interstitial Lung Disease-Nephrotic Syndrome-Epidermolysis Bullosa Syndrome.

2019年5月27日 · Background and objective: ITGA3 is a cell surface adhesion protein that interacts with extracellular matrix proteins which function in cancer metastasis. We examined the relationship of pancreatic ITGA3 expression with the clinical and pathological characteristics of patients with pancreatic cancer.

HGNC Approved Gene Symbol: ITGA3. Integrins are a family of cell surface adhesion molecules. Each integrin consists of a pair of noncovalently associated alpha and beta chains. Integrin alpha-chain sequences are characterized by a 7-fold repeated amino acid motif, of which the last 3 or 4 contain divalent cation-binding sites.

2023年6月4日 · After constructing a three-gene (TMEM80, EIF4EBP1, and ITGA3) purity-independent Cox regression model using machine learning, ITGA3 was identified as a critical integrin subunit gene in pancreatic cancer. ITGA3 is involved in the molecular transformation from the classical to the basal subtype in pancreatic cancer.

2024年12月28日 · 本文详细介绍了ITGA3基因在细胞中的表达调控机制，包括其位置、功能、调控方式以及与其他分子的相互作用，帮助读者全面理解这一重要基因的作用。

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit.

2012年4月19日 · Here we report on three infants with congenital nephrotic syndrome, interstitial lung disease, and skin fragility who were homozygous for mutations in the integrin α 3 gene (ITGA3). Although the...

Up-regulation of integrin subunit alpha 3 (ITGA3) is observed in bladder cancer (BC) clinical samples and tumor cell lines. Silencing ITGA3 enhances apoptosis, inhibits tumor cell migration and invasion, and therefore decreases viability and proliferation of BC cells.

Gene target information for ITGA3 - integrin subunit alpha 3 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.