2024年12月25日 · ITGA4 (Integrin Subunit Alpha 4) is a Protein Coding gene. Diseases associated with ITGA4 include Retinitis Pigmentosa 26 and Isolated Macular Dystrophy. …

ITGA4 is one of the less studied integrin family members , playing a crucial role in mediating cell-cell adhesions that are vital for immune functionality . ITGA4 forms two key integrin complexes …

ITGA4 is an important integrin in the molecular pathogenesis of gastrointestinal stromal tumours and may influence their clinical behaviour. Increased frequencies of pre-HIV alpha4beta7(+) …

2025年2月8日 · Title: Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis. [Association of …

2025年2月11日 · Results: ITGA4 expression was generally low in normal tissues but varied significantly across tumor types, with higher levels in advanced stages and grades. It …

2019年9月10日 · We describe the development and evaluation of exon skipping AOs designed to induce a non-functional isoform and thereby reduce the activity of integrin alpha 4 protein …

2025年2月12日 · ITGA4 played roles in cell adhesion, migration, immune regulation, and pathways like PI3K-Akt and TSC-mTOR. It showed alterations in 22 cancer types, with …

ITGA4 gene-specific CpG methylation in real time using pyrosequencing technology on the PyroMark Q24 System was investigated. Results. ITGA4 was differentially expressed in CLL …

2024年12月10日 · Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded …

2016年5月1日 · The neutralization of integrin α4 (Itga4) is currently used as treatment in multiple sclerosis. Although most studies have focused on its function on lymphocyte migration to the …