2024年12月25日 · ITGA5 (Integrin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with ITGA5 include Lung Cancer and Adult Spinal Cord Glioblastoma Multiforme. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor.

2025年2月1日 · We demonstrate that ITGA5 + synovial fibroblasts might regulate the RA progression by inducing the differentiation of CXCL13 hi PD – 1 hi TPHs and remodelling the proinflammatory microenvironments. Therapeutic modulation of this subpopulation could therefore be a potential treatment strategy for RA.

2025年2月9日 · Title: TLN1 synergizes with ITGA5 to ameliorate cardiac microvascular endothelial cell dysfunction. Integrin alpha5 regulates motility of human monocyte-derived Langerhans cells during immune response.

Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit.

ITGA5 promotes tumor angiogenesis in cervical cancer. The members of the miR-148/152 family inhibit cancer stem cell-like properties in gastric cancer via negative regulation of ITGA5. ITGA5 and ITGB1 contribute to Sorafenib resistance by promoting vasculogenic mimicry formation in hepatocellular carcinoma.

Itga5. Official Name: integrin alpha 5 (fibronectin receptor alpha) [Source:MGI Symbol;Acc:MGI:96604] Ensembl ID: ENSMUSG00000000555. Bio databases IDs: NCBI: 16402 Ensembl: ENSMUSG00000000555: Aliases: integrin alpha 5 (fibronectin receptor alpha) Pathways. Caveolar-mediated Endocytosis Signaling;

整合素α5 (integrin alpha5, ITGA5)为整合素的主要亚单位之一，是细胞内最常见的细胞外基质蛋白异二聚体跨膜受体。 ITGA5通过与细胞外基质相互作用调节细胞骨架组织、细胞迁移、细胞凋亡和信号转导。 近年来研究发现ITGA5在多种肿瘤中异常表达，与肿瘤细胞的黏附、迁移、侵袭以及肿瘤血管的生成密切相关，提示ITGA5有望作为新型肿瘤诊断生物标志物和治疗靶点。 本文就ITGA5结构和功能及其调控肿瘤发生发展的机制进行综述。 整合素α5 (integrin alpha5, …

2021年3月12日 · Our study demonstrated that ITGA5 may act as an essential regulator of tumor immune cell infiltration and a valuable prognostic biomarker in gastrointestinal tumors. Additional work is needed to fully elucidate the underlying mechanisms behind these observations.

itga5基因主要表达于人体各种组织细胞中，如上皮细胞、成纤维细胞和内皮细胞等。研究表明，itga5在肿瘤生长、炎症反应和创伤愈合等过程中发挥着重要作用。 在肝细胞癌中，itga5被认为与肿瘤细胞的血管生成、转移和对抗药物治疗的耐药性密切相关。