2024年12月25日 · ITGB6 (Integrin Subunit Beta 6) is a Protein Coding gene. Diseases associated with ITGB6 include Amelogenesis Imperfecta, Type Ih and Alopecia-Intellectual Disability Syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.

Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. [5][6][7] It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins which span the cell’s membrane, integrating the outside and inside of the cell.

ITGB6是整合蛋白αvβ6的β6亚基，是控制整个异二聚体αvβ6表达的关键性亚单位。 整合素是一种细胞表面跨膜糖蛋白受体，作用是介导细胞与胞外环境的连接。 大多数整合素参与细胞-细胞外基质（ECM）相互作用，而其中一些则参与细胞-细胞相互作用。 整合素在细胞与其周围环境之间传递双向信号，并参与调节细胞的各种行为，包括细胞增殖、迁移、存活、组织侵袭和先天免疫。 整合素是由非共价结合的 α 和 β 亚基组成的异二聚体。 哺乳动物细胞有 18 个不同的整合素 α …

2024年8月16日 · In this study, we evaluate the activity of anti-CD276 antibodies in a chemically-induced murine model of head and neck squamous cell carcinoma. Using models of induced and orthotopic...

Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17158881, PubMed:17545607). It recognizes the sequence R-G-D in its ligands (PubMed:17158881, PubMed:17545607). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17158881, PubMed:17545607).

Integrin β6 (ITGB6), a member of the integrin family of proteins, is only present in epithelial tissues and frequently associates with integrin subunit αv to form transmembrane heterodimers named integrin αvβ6. Importantly, ITGB6 determines αvβ6 expression and availability.

The ITGB6 gene: its role in experimental and clinical biology. Transgenic overexpression of ITGB6 in intestinal epithelial cells exacerbates dextran sulfate sodium-induced colitis in mice. Expression of integrin alphanubeta6 differentiates perihilar cholangiocarcinoma (PHC) from benign disease mimicking PHC.

2024年11月27日 · Title: ITGB6 promotes pancreatic fibrosis and aggravates the malignant process of pancreatic cancer via JAK2/STAT3 signaling pathway. CRISPR/Cas9-mediated knock out of ITGB6 in human OSCC cells reduced migration and proliferation ability.

整联蛋白是由α链和β链组成的异二聚体整合膜蛋白。 编码的蛋白质与 alpha v 链形成二聚体，这种异二聚体可以与纤连蛋白和转化生长因子 beta 1 等配体结合。 交替剪接会产生多个转录变体。 [RefSeq 提供，2013 年 9 月] This gene encodes a protein that is a member of the Integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell.

sgn-b6a是一种针对 整合素β6 （itgb6）的 抗体药物偶联物 （adc）。 它利用可被蛋白酶切割的 MC-VC连接子 ，将针对ITGB6的单克隆抗体h2A2与微管破坏剂 MMAE 连接起来，通过MMAE引发的细胞毒性、旁观者效应及免疫原性细胞死亡（ICD）来实现其抗肿瘤作用。