
淋巴细胞的信号传导(上) - 知乎专栏
顾名思义,ITAM的存在可以激活免疫细胞,ITIM则抑制免疫细胞(虽然某些特殊情况ITAM起抑制作用)。 从分子机制上看,ITAM上的酪氨酸磷酸化后主要招募含有SH2的酪氨酸激酶蛋白( …
Immunoreceptor tyrosine-based inhibitory motif - Wikipedia
ITIM-containing receptors often serve to target immunoreceptor tyrosine-based activation motif (ITAM)-containing receptors, resulting in an innate inhibition mechanism within cells. [3] ITIM …
ITAMs versus ITIMs: striking a balance during cell regulation
In this Perspective, we review the molecular interactions of ITAM- and ITIM-bearing proteins and consider their importance in regulating the outcome of immune cell stimulation by antigens.
免疫受体酪氨酸活化基序 - 维基百科,自由的百科全书
免疫受体酪氨酸活化基序 (英語: immunoreceptor tyrosine-based activation motif,缩写 ITAM)是一个由十多个 氨基酸 构成的保守序列,常出现在 免疫系统 某些细胞的 跨膜蛋白 的 …
ITIM和ITAM - 百度文库
(1)ITIM是免疫受体酪氨酸抑制基序的英文缩写,基本组成是:I (异亮)/V (缬)XY (酪)XXL (亮),其酪氨酸被磷酸化后,可招募蛋白酪氨酸磷酸酶 (PTP),并使之活化,PTK参与的激活信号转导通路即 …
ITAM - 百度百科
生物学中,ITAM是免疫受体酪氨酸激活基序(Immunoreceptor tyrosine-based activation motif)的英文缩写,基本组成是:YXXL/V,活化受体与相应配体结合后,在细胞膜相连的一 …
免疫受体酪氨酸抑制基序 - 百度百科
ITIM即免疫受体酪氨酸抑制基序,主要存在于某些抑制性受体分子胞内部分,与ITAM不同,ITIM中的酪氨酸发生磷酸化后,可被PTP分子上的 SH2结构域 所结合,从而招募PTP并使之活化, …
ITIM/ITAM Immunoreceptors and Related Molecules
Immunoreceptor tyrosine-based activation motif (ITAM), (in the antagonistic case ITIM, I refers inhibition) is found in the tails of important cell signaling molecules involved in cell signaling …
The many faces of ITAMs: Trends in Immunology - Cell Press
In the immune system and beyond, signals transduced through cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) control a variety of key cellular responses, including …
basic-9-ITAM - 知乎
Immunoreceptor tyrosine-based activation motif (ITAM) 是一种存在于细胞 膜受体的结构域。 ITAM是一种由 6-8个氨基酸残基 组成的 保守肽段,其序列为Yxx (L/I)x (6-8)Yxx (L/I),其中 x …