2024年12月25日 · ITPKB (Inositol-Trisphosphate 3-Kinase B) is a Protein Coding gene. Diseases associated with ITPKB include Hematologic Cancer and Combined Immunodeficiency. Among its related pathways are superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism and Inositol phosphate metabolism.

The protein encoded by the ITPKB gene is one of 3 isoforms of Inositol-trisphosphate 3-kinase expressed in humans. ITPKB protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate , which releases calcium from intracellular store in the endoplasmic reticulum by gating the inositol ...

由该蛋白编码的蛋白通过将第二信使肌醇 1,4,5-三磷酸磷酸化为 Ins (1,3,4,5) P4 来调节肌醇磷酸代谢。 这种编码蛋白的活性负责调节大量在细胞信号传导中很重要的肌醇多磷酸盐的水平。 钙/钙调蛋白和蛋白质磷酸化机制均控制其活性。 [RefSeq 提供，2008 年 7 月] The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins (1,3,4,5)P4.

2024年3月4日 · Validation through glioma tissue arrays and the Xiangya cohort confirmed substantial upregulation of inositol 1,4,5-triphosphate (IP3) kinase B (ITPKB) in the recurrence group, correlating with...

Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency. study also suggests a distinctive signaling function of IP4 that regulates NOX4.

肌醇-1,4,5-三磷酸（ip 3）激酶b（itpkb）是一种普遍表达的脂质激酶，可以使ip 3失活，一种辅助信使，可刺激钙从内质网（er）释放。 全基因组关联研究已经确定了ITPKB基因位点的常见变异，这些变异与散发性帕金森氏病（PD）的风险降低有关。

Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme. Headpiece domain of dematin regulates calcium mobilization and signaling in platelets. 这个蛋白质通过将第二信使肌醇1,4,5-三磷酸磷酸化来调节肌醇磷酸代谢，从而生成肌醇1,3,4,5-四磷酸。 这个编码蛋白质的活性负责调节大量肌醇多磷酸的水平，这些肌醇多磷酸在细胞信号传导中起着重要作用。 钙/钙调素和蛋白质磷酸化机制都控制其活性。 [由RefSeq，2008 …

itpkb蛋白是一种激酶，trim25和iptkb的互作是否通过调控激酶结构域发挥功能，需要进一步探究。 作者通过构建系列ITPKB截短 突变体 ，进行 Co-IP检测 分析，结果表明ITPKB激酶结构域是其与Trim25结合所必需的(图1g-h)

Inositol-1,4,5-triphosphate (IP 3) kinase B (ITPKB) is a ubiquitously expressed lipid kinase that inactivates IP 3, a secondary messenger that stimulates calcium release from the endoplasmic reticulum (ER). Genome-wide association studies have identified common variants in the ITPKB gene locus associated with reduced risk of sporadic Parkinson ...

Predicted to enable inositol hexakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in cellular response to calcium ion; inositol phosphate metabolic process; and phosphatidylinositol phosphate biosynthetic process.