2020年12月3日 · We have created the first 3D adipose tissue organoid model which could contain and maintain resident immune cell populations of the stromal vascular fraction (SVF) and proved to be effective in...

Mechanistically, GCH1 overexpression increased BH4, nitric oxide and hydrogen peroxide, and these changes were associated with increased release of histamine and serotonin and degranulation of mast cells. LysM‐driven GCH1 knockout had opposite effects, and pharmacologic inhibition of GCH1 provided even stronger itch suppression.

2019年5月30日 · Mast cells are effector cells in the immune system that play an important role in the allergic airway inflammation. Recently, it was reported that BLT2, a low-affinity leukotriene (LT) B 4 receptor, plays a pivotal role in the pathogenesis of allergic airway inflammation through its action in mast cells.

Mast cells (MCs) are heterogeneous tissue-resident effector cells thought to play central roles in allergic inflammatory disease, yet the degree of heterogeneity and nature of these roles has remained elusive. In recent years, advances in tissue …

2023年1月24日 · Our findings underline the unique position of mast cells at the neuro-immune interface and highlight substance P-driven mast cell BH4 production as promising therapeutic targets for the treatment of postoperative pain. Postoperative pain affects most patients after major surgery and can transition to chronic pain.

2025年1月10日 · This review provides an overview of the latest developments in the MC field, with a focus on our evolving understanding of mast cell progenitors, MC heterogeneity across tissues and inflammation, mast cell interactions with neighboring immune and structural cells, and processes regulating mast cell activation.

2024年12月10日 · Mast cells act as “signal converters,” translating immunological and tissue signals into host-protective behaviors. They sense antigen and possibly toxins driving avoidance behavior, which can prevent inflammation and tissue damage. Beyond classical immunity, mast cells rapidly activate antigen expulsion responses and initiate nociception.

2025年1月10日 · Mast cells (MCs) are heterogeneous tissue-resident effector cells that are thought to play central roles in allergic inflammatory disease, yet the degree of heterogeneity and nature of these roles has remained elusive.

These studies have greatly advanced our understanding of how mast cells exert non-histaminergic itch, pain, and drug-induced pseudoallergy by interacting with sensory neurons. Recent studies have also characterized mast cell activation and regulation by interleukin-33 (IL-33) and other cytokines and by non-coding RNAs.

2024年6月11日 · Mast cells are sensors of the environment, able to respond promptly and selectively to a wide variety of stimuli. The responses of MCs to different stimuli are extremely heterogeneous and can be conditioned by the microenvironment and intrinsic factors.

2021年10月19日 · Mast cells (MCs) contribute prominently to all allergic diseases, yet are still poorly understood owing to their exclusive residence in tissues. Recently, the use of RNA-sequencing, proteomics, and other technological advances have accelerated the acquisition of new knowledge.

2005年6月1日 · Sequential immunomagnetic isolation with 2 monoclonal antibodies was used to purify and characterize an undifferentiated mast cell in adult mouse bone marrow that had not been previously recognized. This cell represents 0.02% of the cells in the bone marrow, is CD34 +, CD13 +, and c-kit +, and does not express FcϵRI.

The cell–cell adhesion of mast cells and fibroblasts is crucial for fibrosis. Mast cell mediators, including cytokines and proteases, play contradictory roles in the fibrotic process. Here, we review the double-edged role of mast cells in inflammation and fibrosis.

Mast cells (MCs) are abundant in almost all vascularized tissues. Furthermore, their anatomical proximity to lymphatic vessels and their ability to synthesize, store and release a large array of inflammatory and vasoactive mediators emphasize their significance in the regulation of the lymphatic vascular functions.

2025年1月2日 · Mast cells (MCs) expressing a distinctive protease phenotype (MC T s) selectively expand within the epithelium of human mucosal tissues during type 2 (T2) inflammation. While MC T s are phenotypically distinct from subepithelial MCs (MC TC s), signals driving human MC T differentiation and this subset’s contribution to inflammation remain ...

Immunohistochemical staining of challenged lung sections provides evidence for mast cell activation. Mast cell protease, mMCP-1, was detected in the smaller lower airways, alveolar spaces, and on alveolar macrophages from both CCR3-deficient and wild-type mice (data not …

2025年1月15日 · Mast cells are derived from CD34 + and CD117 + hematopoietic stem cells in the bone marrow, primarily manifesting as abundant secretory granules in tissues, particularly in areas that...

2003年7月1日 · cDNAs were recently isolated from BALB/c mouse mast cells (MCs) that encode the new signaling protein mouse Ras guanine nucleotide releasing protein 4 (mRasGRP4). The present study evaluates the expression pattern and biological activity of mRasGRP4 in a variety of mouse strains. As assessed immunoh …

2022年7月8日 · Given that protein kinases play a crucial role in signal transduction, here we show that Microtubule Associated Serine/Threonine Kinase Family Member 4 (Mast4) serves as an important mediator of...

1 天前 · Mast cells release granules in a biphasic manner—an immediate discharge of preformed mediators like histamine, tryptase, and chymase, followed by a slower synthesis of lipid-derived mediators such as prostaglandins and leukotrienes. This prolonged response influences local tissue dynamics. Basophils, in contrast, degranulate more rapidly but ...