The c-Jun N-terminal kinases consist of ten isoforms derived from three genes: JNK1 (four isoforms), JNK2 (four isoforms) and JNK3 (two isoforms). [2] Each gene is expressed as either …

JNK，（c-Jun 氨基末端 激酶，c-Jun N-terminal kinase）又被称为应激活化 蛋白激酶 (stress-activated protein kinase, SAPK)，是 哺乳类 细胞中 MAPK （mitogen -activated protein …

应激活化蛋白激酶 (SAPK)/Jun 氨基末端激酶 (JNK) 是 MAPK 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 GPCR 激动剂激活。 应激反应信号经 Rho 家族（Rac、Rho …

2025年1月1日 · JNK1, rather than JNK2, causally contributes to TGF-β1-induced epithelial-to-mesenchymal transition (EMT) and pro-fibrotic gene expression, suggesting that JNK1 may be …

JNK 也称作 SAPKs（stress-activated protein kinases，应激激活的蛋白激酶），主要包括 JNK1（SAPKα，MAPK8）、JNK2（SAPKβ，MAPK9） …

Here we report that JNK1, but not JNK2, is essential for tumor necrosis factor alpha (TNF-α)-induced c-Jun kinase activation, c-Jun expression, and apoptosis. Using mouse fibroblasts …

2004年9月10日 · Different c-Jun N-terminal kinases (JNKs) are activated by a plethora of signals and phosphorylate substrates such as c-Jun, which is required for efficient cell cycle …

JNK1 induces apoptosis, whereas JNK2 promotes carcinogenesis in an AP1-dependent manner. SCCA1 promotes SCC via inhibition of JNK1 and CYLD inhibits SCC via suppression of …

2021年3月31日 · Here we found that the germinal ablation of the MAPK c-Jun N-Terminal Kinase isoform 1 (JNK1) results in a significant reduction of myelin in the cerebral cortex and corpus …

1994年3月25日 · Here, we describe the molecular cloning and characterization of JNK1, a distant relative of the MAP kinase group that is activated by dual phosphorylation at Thr and Tyr …