
A folic acid-decorated nanoparticles loaded JQ1 for oral …
2024年3月1日 · In this study, a folic acid (FA) decorated tumor-targeted nanocarrier for JQ1 was designed successfully, which showed outstanding performance in tumor targeting and …
Fine-Tuning the Physicochemical Properties of Poly(lactic Acid ...
2025年1月6日 · To address these challenges, the optimization of JQ1 delivery has been accomplished through polylactide (PLA) nanoparticles. PLA derivatives with varying molecular …
Fine-Tuning the Physicochemical Properties of Poly(lactic Acid ...
This study highlights the potential of PLA-derived NPs as advanced DDS for the BET inhibitor JQ1. By synthesizing PLA derivatives using a biocompatible Zn-based catalyst, we achieved …
Fine-Tuning the Physicochemical Properties of Poly(lactic Acid
2025年1月6日 · This study highlights the potential of PLA-derived NPs as advanced DDS for the BET inhibitor JQ1. By synthesizing PLA derivatives using a biocompatible Zn-based catalyst, …
Methylarginine targeting chimeras for lysosomal degradation of ...
2024年10月16日 · We developed a heterobifunctional small molecule, methylarginine targeting chimera (MrTAC), that recruits PRMT1 to a target protein for induced degradation in …
叶酸修饰的纳米颗粒负载JQ1用于口腔鳞状细胞癌治疗,Chinese …
因此,我们通过将jq1 [含溴结构域蛋白4(brd4)的小分子抑制剂]封装到叶酸(fa)修饰的纳米颗粒(peg- pla),可以延长jq1的半衰期并靶向肿瘤组织。 然后,从该纳米颗粒中释放的 JQ1 …
西华大学最新研究:叶酸修饰纳米粒负载JQ1治疗口腔鳞状细胞癌
2024年3月1日 · 这项研究提出了一种新的治疗oscc的策略,即通过将jq1封装到fa修饰的纳米粒子中,实现对肿瘤组织的靶向性。 此外,这种治疗方法还可以抑制肿瘤血管生成和M2型巨噬细胞 …
Synthesis, SAR, and application of JQ1 analogs as PROTACs for …
2024年10月1日 · JQ1 is a wonder therapeutic molecule that selectively inhibits the BRD4 signaling pathway and is thus widely used in the anticancer drug discovery program. Due to its …
《荷载紫杉醇与JQ1 PLGA纳米粒的制备及抗肿瘤作用研究》
2025年1月8日 · 荷载紫杉醇与JQ1的PLGA纳米粒作为一种新型的抗肿瘤药物载体,具有提高药物溶解度、增强药物稳定性、降低药物副作用等优点。 本研究旨在制备荷载紫杉醇与JQ1 …
A folic acid-decorated nanoparticles loaded JQ1 for oral
2023年4月1日 · JQ1 inhibited the proliferation and induced apoptosis of GC cells in vitro. Besides, JQ1 suppressed the migration and invasion of cancer cells by inducing MET.