Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac …
2019年8月14日 · In the current study, we demonstrate that JQ1 profoundly inhibits expression of activation markers and extracellular matrix proteins in cultured cardiac fibroblasts treated with …
Chromatin remodelling drives immune cell–fibroblast ... - Nature
2024年10月23日 · We captured 41,626 cells from sham, TAC vehicle-treated (TAC) or TAC JQ1-treated (TAC JQ1) hearts, and identified 20 transcriptional clusters by uniform manifold …
A transcriptional switch governs fibroblast activation in ... - Nature
2021年6月23日 · One month of treatment with a small-molecule BET bromodomain inhibitor, JQ1 9, that was started 18 days after the induction of heart failure through left ventricle pressure …
《自然》：发现治疗心衰新靶点！科学家发现，转录开关的控制可 …
2021年7月7日 · 在这个研究中，他们使用了主动脉缩窄术(tac)来诱导小鼠建立心衰模型，建模18天时开始进行bet抑制剂jq1治疗，1个月后发现jq1可以显著改善小鼠的左心室收缩功能。
BET Bromodomains Mediate Transcriptional Pause Release in …
BET bromodomain inhibition of TAC-treated hearts led to a higher ratio of promoter to elongating gene body Pol II compared to TAC at all active genes (Figure 6E) and at TAC-induced genes …
A Transcriptional Switch Governs Fibroblast Activation in Heart …
One month of treatment with a small molecule BET bromodomain inhibitor, JQ1 9, commenced 18 days after heart failure induction by left ventricle (LV) pressure overload via transvers aortic …
Inhibition of BRD4 attenuates transverse aortic ... - ScienceDirect
2019年2月1日 · To study the function of BRD4 in vivo, we carried out a TAC procedure followed by intraperitoneal injection of JQ1 (50 mg/kg/day) from 1 day after TAC. Intraperitoneal …
BET bromodomain inhibition suppresses innate inflammatory and ...
2017年5月5日 · The overall objective of this study was to determine whether BET bromodomain inhibition with the small-molecule JQ1 could treat HF in well-established rodent models (TAC …
BET acetyl-lysine binding proteins control pathological cardiac ...
2013年10月1日 · JQ1, a small molecule inhibitor of bromodomain and extraterminal (BET) acetyl-lysine reader proteins, was identified in a high throughput screen designed to discover novel …
转录因子成新靶点！Nature发文：转录开关调控心脏成纤维细胞活 …
2021年7月2日 · 如果使用横向主动脉缩窄(tac)通过左心室压力超负荷诱导心力衰竭18天后，开始使用小分子bet抑制剂jq1治疗小鼠一个月，可显著改善小鼠的左心室收缩功能，停药两周则会导 …