2019年8月14日 · In the current study, we demonstrate that JQ1 profoundly inhibits expression of activation markers and extracellular matrix proteins in cultured cardiac fibroblasts treated with TGF-β, and in cardiac fibroblasts isolated from LVs of animals subjected to TAC. JQ1 also suppressed the contractile activity of cardiac fibroblasts in association ...

2024年10月23日 · We captured 41,626 cells from sham, TAC vehicle-treated (TAC) or TAC JQ1-treated (TAC JQ1) hearts, and identified 20 transcriptional clusters by uniform manifold approximation and...

2021年6月23日 · One month of treatment with a small-molecule BET bromodomain inhibitor, JQ1 9, that was started 18 days after the induction of heart failure through left ventricle pressure overload using...

2021年7月7日 · 在这个研究中，他们使用了主动脉缩窄术(tac)来诱导小鼠建立心衰模型，建模18天时开始进行bet抑制剂jq1治疗，1个月后发现jq1可以显著改善小鼠的左心室收缩功能。

BET bromodomain inhibition of TAC-treated hearts led to a higher ratio of promoter to elongating gene body Pol II compared to TAC at all active genes (Figure 6E) and at TAC-induced genes that were reversed by JQ1 (Figure 6F).

One month of treatment with a small molecule BET bromodomain inhibitor, JQ1 9, commenced 18 days after heart failure induction by left ventricle (LV) pressure overload via transvers aortic constriction (TAC), significantly improved LV systolic function in mice (Fig.1a).

2019年2月1日 · To study the function of BRD4 in vivo, we carried out a TAC procedure followed by intraperitoneal injection of JQ1 (50 mg/kg/day) from 1 day after TAC. Intraperitoneal administration of JQ1 at 50 mg/kg/day has previously been shown to potently inhibit BRD4 function in adult mice without significant toxicity [ 18 , 23 ].

2017年5月5日 · The overall objective of this study was to determine whether BET bromodomain inhibition with the small-molecule JQ1 could treat HF in well-established rodent models (TAC and MI) and attenuate ET-1– induced pathologic remodeling in human iPSC-CMs.

2013年10月1日 · JQ1, a small molecule inhibitor of bromodomain and extraterminal (BET) acetyl-lysine reader proteins, was identified in a high throughput screen designed to discover novel small molecule regulators of cardiomyocyte hypertrophy.

2021年7月2日 · 如果使用横向主动脉缩窄(tac)通过左心室压力超负荷诱导心力衰竭18天后，开始使用小分子bet抑制剂jq1治疗小鼠一个月，可显著改善小鼠的左心室收缩功能，停药两周则会导致左心室收缩功能消退，而再次启动治疗则能够使小鼠左心室功能恢复正常并且即使停药也 ...