Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate …

2024年12月25日 · JAG2 (Jagged Canonical Notch Ligand 2) is a Protein Coding gene. Diseases associated with JAG2 include Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 27 and …

Notch受体是一种跨膜受体，包括Notch1-4四种亚型，在信号通路的激活中起到核心作用。 JAG1-2和DLL1：编码Notch的配体，与Notch受体相互作用来启动信号通路。 JAG1和JAG2属 …

经处理的受体随后通过内体转运到质膜，从而通过 Deltex 调控和 NUMB 抑制的方式与配体结合。在哺乳动物信号发送细胞中，Delta-like（DLL1、DLL3、DLL4）和 Jagged（JAG1、JAG2） …

JAG2-mediated Notch activation confers phenotypic and functional aspects of Langerhans cell histiocytosis to dendritic cells. JAG2 is often expressed by CD138(+) primary cells. Our results …

Notch 信号通路是一种细胞间信号机制，对胚胎的正常发育至关重要。 Notch 基因家族的成员编码对各种细胞命运决定至关重要的跨膜受体。 由该基因编码的蛋白质是激活 Notch 和相关受体 …

2025年1月4日 · Clinical resource with information about JAG2, Muscular dystrophy, limb-girdle, autosomal recessive 27, and available tests. There are links to practice guidelines and …

2024年4月19日 · Jag2-/-lung tumors exhibited higher frequencies of macrophages that expressed immunostimulatory mediators and triggered T cell-dependent anti-tumor immunity. …

2021年5月6日 · JAG2 encodes the Notch ligand Jagged2. The conserved Notch signaling pathway contributes to the development and homeostasis of multiple tissues, including …

2021年10月13日 · The JAG2 gene encodes a transmembrane protein that is a ligand for the Notch (see NOTCH1, 190198) family of transmembrane receptors that are critical for various …