Germline Gain-of-Function JAK3 Mutation in Familial Chronic ...
2020年11月5日 · Here we report on the discovery of a germline GOF JAK3 mutation as a first germline cause of CLPD-NK. Two individuals from one nonconsanguineous family (mother …
JAK/STAT proteins and their biological impact on NK cell …
2019年11月1日 · JAK3 is a JAK family member that is involved in NK cell development, proliferation, and function (Ghoreschi et al., 2009). In contrast with other JAK members, JAK3 …
Frontiers | JAK/STAT Cytokine Signaling at the Crossroad of NK …
2019年11月11日 · Jak3 −/− mice are immunocompromised, display severe developmental defects in the lymphoid lineage and lack NK, T and B cells (23, 53). The in vivo administration of …
JAK/STAT Cytokine Signaling at the Crossroad of NK Cell ... - PubMed
2019年11月12日 · Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a critical role in anti-viral and anti-tumor responses. NK cells develop in the …
Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity …
Germline JAK3 GOF mutations have also been identified in the context of familial chronic lymphoproliferative disorder of NK cells (CLPD-NKs) . JAK3 has further been observed to be …
Janus kinase 3: the controller and the controlled - PMC
Janus kinase (JAK)-signal transducer and activators of transcription (STAT) signaling pathways play crucial roles in lymphopoiesis. In particular, JAK3 has unique functions in the lymphoid …
Recurrent somatic JAK3 mutations in NK-cell enteropathy
2019年9月19日 · The identification of recurrent mutations in NK-cell enteropathy support a neoplastic origin, and it may be considered a distinct neoplastic disease entity with the …
Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity
2024年3月4日 · The structure, function and impacts of both GOF and LOF mutations of JAK3 are highly conserved, making animal models highly informative. This review details the biology of …
JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis
2019年12月18日 · We assessed the effects of in vivo administration of a JAK1/3 inhibitor, tofacitinib, vs. a more selective JAK3 inhibitor, PF-06651600, focusing on NK cells from …
JAK3 deregulation by activating mutations confers invasive …
Extranodal, nasal-type natural killer (NK)/T-cell lymphoma (NKCL) is an aggressive malignancy with poor prognosis in which, usually, signal transducer and activator of transcription 3 …