Adult T-cell leukemia-lymphoma (ATL) is an aggressive T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1) infection that often occurs in HTLV-1-endemic areas, such as Japan, the Caribbean islands, Central and South America, Intertropical Africa, …

At early 1980´s was evidenced that Japan was a high endemic area for HTLV-1. However, it was shown that Japan has an uneven distribution of HTLV-1 carriers, with the greatest prevalence in Southwestern Japan.

2025年2月5日 · However, the incidence of HTLV-1 infection appears to be high among adolescents and young adults in Japan, especially in non-endemic areas. The clinical significance of HTLV-1 infections, other than ATL and HAM/TSP, has recently been documented.

2020年4月9日 · In Japan, an antenatal HTLV-1 antibody screening program has been implemented on a nationwide scale for preventing MTCT of the virus. Pregnant women tested positive on a confirmatory or PCR test are identified as HTLV-1 carriers.

2021年2月5日 · Human T-cell leukemia virus type 1 (HTLV-1) has worldwide distribution and is considered endemic in southwestern Japan. HTLV-1 infection has been associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) besides other diseases.

2025年3月20日 · The estimated number of HTLV-1 carriers worldwide has been estimated as 5–10 million, with several highly endemic regions including southwestern Japan, sub-Saharan Africa, South America, the Caribbean, and specific areas in …

2025年2月26日 · A high HTLV-1 proviral load (PVL) in carriers has been used as a risk factor for ATL development and PVLs are considered to remain unchanged over time among carriers. This single-center analysis used a cohort from a prospective observational study of HTLV-1 carriers in Japan (JSPFAD).

3 天之前 · In Japan, we have a prospective cohort study of HTLV-1 infected individuals, JSPFAD (Joint Study on Predisposing Factors of ATL Development) with a history of around 20 years. While primarily focused on HTLV-1 carriers, JSPFAD also includes a …

Human T-cell leukemia virus type-1 (HTLV-1), a major source of adult T-cell leukemia and related diseases, is endemic to southwestern Japan. Mother-to-infant transmission via breast milk is an important route of infection, and establishing programs to …

2016年8月23日 · Human T-lymphotropic virus 1 (HTLV-1) infection has an especially high prevalence in Japan. Transmission has been confirmed in infancy through breastfeeding; however, little is known about the epidemiological aspects of new HTLV-1 infections later in life.