Japanese encephalitis virus-primed CD8+ T cells prevent antibody ...
2020年9月7日 · We show that sera and IgG from JEV-vaccinated humans and JEV-inoculated mice cross-reacted with ZIKV, exacerbated lethal ZIKV infection upon transfer to mice, and …
Japanese encephalitis virus–primed CD8 - National Center for ...
2020年9月9日 · Chen et al. show that Japanese encephalitis virus (JEV)–elicited CD8 + T cells and antibodies play protective and pathogenic roles in Zika virus–infected wild-type C57BL/6 …
CD8 T cells protect adult naive mice from JEV-induced morbidity …
2017年2月2日 · Our data show that effector CD8 T cells play a protective role during primary infection possibly by preventing the breach in BBB and neuronal damage. Japanese …
PD1+CCR2+CD8+ T Cells Infiltrate the Central Nervous System …
JEV infection dramatically enhanced the expression of programmed death 1 (PD-1) on infiltrating CD8 + T cells in the brain, as compared to that on peripheral CD8 + T cells in the spleen. This …
Multifront assault on antigen presentation by Japanese …
2010年8月1日 · In this study, we found that JEV induced the subversion of CD8(+) T cell responses in a transient manner that was closely correlated with viral multiplication. …
Myeloid-Derived Suppressor Cells Induce Exhaustion-Like CD8
CD8 + T cells, which are crucial to the adaptive immune response, play an important role in managing JEV infections by directly destroying infected cells and producing antiviral …
Pivotal Role of Antibody and Subsidiary Contribution of CD8
JEV infection resulted in extensive CD8 + T cell activation, judged by upregulation of surface markers CD69 and CD25 and cytokine production after stimulation with a JEV NS4B protein …
Human T cell responses to Japanese encephalitis virus in health …
Healthy donors exposed to Japanese encephalitis (JE) virus show a CD8 + T cell response that cross reacts with other flaviviruses. Patients that recovered from JE show a CD4 + T cell …
Japanese encephalitis virus E protein domain III ... - ScienceDirect
2024年7月1日 · Recent findings by ourselves and other labs showed that JEV-elicited antibodies (Abs) and CD8 + T cells exacerbate and protect against subsequent ZIKV infection, …
TLR9 promotes monocytic myeloid-derived suppressor cell …
2024年7月1日 · Regarding adaptive immunity, JEV inhibits the maturation of dendritic cells and impairs their antigen-presenting function through the Toll-like receptor (TLR) pathway, thereby …