
Inhibition of JNK activation through NF-κB target genes | Nature
2001年11月15日 · Here we show that in addition to inhibiting caspases, the IKK/NF-κB pathway negatively modulates TNF-α-mediated JNK activation, partly through NF-κB-induced X …
Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK ...
2001年11月15日 · Here we report that NF-κB complexes downregulate the c-Jun amino-terminal kinase (JNK) cascade 3, thus establishing a link between the NF-κB and the JNK pathways. …
Linking JNK signaling to NF-κB: a key to survival
2004年10月15日 · During an inflammatory response, NF-κB activation antagonizes apoptosis induced by tumor necrosis factor (TNF)-α, a protective activity that involves suppression of the …
Selective inhibitors for JNK signalling: a potential targeted …
Emerging evidence show that JNK promoted tumour progression is involved in various cancers, that include human pancreatic-, lung-, and breast cancer. The pro-survival JNK oncoprotein …
JNK - 百度百科
JNK,(c-Jun 氨基末端 激酶,c-Jun N-terminal kinase)又被称为应激活化 蛋白激酶 (stress-activated protein kinase, SAPK),是 哺乳类 细胞中 MAPK (mitogen -activated protein …
the NF-kB and JNK pathways. Tang et al.35 and De Smaele et al.36 have independently demonstrated that TNFa induces prolonged JNK activation in NF-kB activation-deficient cells,
NF-kappaB and JNK: an intricate affair - PubMed
With respect to TNFalpha, the NF-kappaB-mediated suppression of apoptosis involves inhibition of the c-Jun-N-terminal kinase (JNK) cascade.
NF‐κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis
2010年11月28日 · Several signal transduction pathways such as NF- κ B and JNK are involved in the pathogenesis of these viruses. For example, the HCV core and HBx proteins are the most …
c-Jun N末端激酶(JNK)抑制剂的最新进展,Current Medicinal …
c-Jun N末端激酶(JNKs)是丝裂原激活的蛋白激酶(MAPK)信号通路的成员,在许多疾病的发病机理中都起着关键作用,包括癌症,炎症,帕金森氏病,阿尔茨海默氏病,心血管疾病,肥 …
Alzheimer's Dementia︱最新科学假说!JNK为神经退行性疾病的 …
2021年5月25日,来自长江大学—赫拉德茨˙克拉洛韦大学 (捷克)毒理学联合实验室的 吴庆华 和 Kamil Kuca 教授团队在 Alzheimer's & Dementia 在线发表了题为 《Hypothesis: JNK Signaling …
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