2 天之前 · JMJD1A play roles in spermatogenesis, energy metabolism, regulation of stem cell as well as the initiation and progress of cancer. Here, we review the structure, catalytic …

2015年5月7日 · Histone 3 lysine 9 (H3K9) demethylase JMJD1A regulates β-adrenergic-induced systemic metabolism and body weight control. Here we show that JMJD1A is phosphorylated …

2018年4月19日 · JMJD1A (also known as JHDM2A or KDM3A) is an histone H3 lysine 9 (H3K9) dimethyl and monomethyl (me2/1) demethylase, with broad functional roles in stem cell …

2015年5月7日 · Our results show that JMJD1A has two important roles in regulating hormone-stimulated chromatin dynamics that modulate thermogenesis in BATs. In one role, JMJD1A is …

2021年9月3日 · We determined HIF-1α and Jumonji domain-containing protein 1 A (JMJD1A) expression by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and …

2022年1月12日 · JMJD1A (also called lysine demethylase 3A [KDM3A]) belongs to the Jumonji C family of histone demethylases. It specifically removes the repressive mono- or di-methyl …

在这项研究中，我们在肾细胞和结肠癌细胞系中鉴定了依赖 jmjd1a 的缺氧诱导基因子集。 JMJD1A 通过降低启动子组蛋白甲基化来调节缺氧条件下肾上腺髓质素 (ADM) 和生长分化因子 …

2020年4月1日 · Here, we found that histone demethylase JMJD1A regulates expression of a different set of DDR genes largely through c-Myc. Inhibition of JMJD1A delayed the resolution …

前列腺癌细胞中的异位 jmjd1a 表达促进体外增殖、迁移和侵袭，以及体内肿瘤发生；jmjd1a 击倒表现出相反的效果。 机械地，我们揭示了 JMJD1A 直接与 Snail 基因启动子相互作用并调节 …

2022年9月1日 · The JMJD1 subfamily includes JMJD1A, JMJD1B, and JMJD1C (or KDM3A, B, and C, respectively), which all contain 2 conserved domains required for catalytic activities, 25, …