2013年5月15日 · KDM4/JMJD2 proteins are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26. This protein family consists of three ~130-kDa proteins …

2022年9月1日 · JMJD2 is one of the largest JMJD subfamilies and is comprised of JMJD2A-D proteins, also referred to as KDM4A-D. JMJD2 family members take active parts in multiple …

2021年1月13日 · Histone demethylase JMJD2 (also known as KDM4) family proteins have been previously shown to support self-renewal and differentiation of stem cells. However, their roles …

Here we report studies on the inhibition of the JMJD2 subfamily of histone demethylases, employing binding analyses by nondenaturing mass spectrometry (MS), dynamic …

2016年10月6日 · Recent research shows dysregulation in epigenetic regulatory mechanisms, particularly the transcriptionally repressive di- and tri-methylation of histone 3 lysine 9 …

2011年5月9日 · JMJD2 proteins are lysine trimethyl–specific histone demethylases that catalyze the demethylation of trimethylated H3K9 (H3K9me3) and H3K36 (H3K36me3). Genome-wide …

KDM4/JMJD2 proteins are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26. This protein family consists of three ~130 kDa proteins (KDM4A–C) and …

2013年1月8日 · JMJD2 lysine demethylases (KDMs) participate in diverse genomic processes. Most JMJD2 homologs display dual selectivity toward H3K9me3 and H3K36me3, with the …

KDM4/JMJD2是H3K9-和H3K36-特异性去甲基化酶，被认为有望成为携带MLL易位的急性髓系白血病(AML)的治疗靶点。Karl Agger等人研究耗竭KDM4活性对正常造血的长期影响，以探讨持 …

2023年7月15日 · Methods: To evaluate the effects of Jumonji C domain-containing (JMJD2) protein subfamily JMJD2A-2D proteins on HBV replication, we used lentivirus-based RNA …