Juvenile myelomonocytic leukemia (JMML) is a rare leukemia affecting children. It is known to be associated with multiple juvenile xanthogranulomas (JXG) and neurofibromatosis type 1 and usually presents before the self-resolution of the JXG. Skin rashes may frequently occur with JMML but are most commonly maculopapular type.

2021年11月23日 · Several translocations have been reported in diseases that phenotypically meet criteria of JMML, including most recently in ALK, SOS1, and FLT3, that lead to hyperactivated Ras signaling. 15,34 Fusions involving FIP1L1-RARA, HCMOGT-1-PDGFRB, NDEL1-PDGFRB, and NUP98-HOXA11 have also previously been found in patients diagnosed clinically with ...

skin rashes; cough and wheezing; Diagnosing JMML. Your child will need a number of tests if their doctor suspects they have JMML. Your child might have more than one test on the same day. And they only have the tests their team think are needed. These tests aren’t generally painful. But, your child will have to keep still for some of them ...

Juvenile myelomonocytic leukemia (JMML), belonging to the category of myeloproliferative/myelodysplastic syndromes, is a rare pediatric hematologic malignancy with frequent skin manifestations commonly in the form of rashes. However, these rashes are not always biopsied and their immunophenotype stu …

Incidence of skin lesions in JMML has been reported to be 36-48% with most presenting as nonspecific reactive maculopapular rash, also known as leukemids. An annual review even after regression of skin lesions is necessary to follow up on recurrence of JXG, and/or the development of associated JMML that can rarely present as leukemic cutis, as ...

2011年11月1日 · Children with JMML typically present with marked splenomegaly and hepatomegaly and varying degrees of lymphadenopathy, pallor, and skin rash. The peripheral blood usually show leukocytosis, absolute monocytosis, often with dysplastic features, anemia, and thrombocytopenia.

Skin rashes, ecchymosis, lymphadenectasis, and ChE reduction are more common in children with JMML than in those with CML or MDS, while dyshaematopoiesis is less common. In addition, CD14 level increases significantly in children with JMML.

Symptoms of JMML. Patients with JMML may experience symptoms, such as: Dry cough; Difficulty breathing or shortness of breath; Bone and joint pain; Swollen belly, abdominal pain and lack of appetite – due to an enlarged liver, spleen or both; Frequent infections – due to low levels of healthy white blood cells

Several translocations have been reported in diseases that phenotypically meet criteria of JMML, including most recently in ALK, SOS1, and FLT3, that lead to hyperactivated Ras signaling. 15,34 Fusions involving FIP1L1-RARA, HCMOGT-1-PDGFRB, NDEL1-PDGFRB, and NUP98-HOXA11 have also previously been found in patients diagnosed clinically with ...

Children with JMML typically present with marked splenomegaly and hepatomegaly and varying degrees of lymphadenopathy, pallor, and skin rash. The peripheral blood usually show leukocytosis, absolute monocytosis, often with dysplastic features, anemia, and thrombocytopenia.