FOXO转录因子 家族通过调节基因表达参与细胞的生理事件，包括凋亡、细胞周期控制、葡萄糖代谢、氧化应激抵抗和寿命延长。 FOXO蛋白的一个核心调控机制是在胰岛素或多种生长因子刺 …

2009年10月23日 · Here, we identified Jafrac1, a Drosophila homolog of human Peroxiredoxin II (hPrxII), as a downstream effecter of JNK/FOXO signaling in neurons that enhances stress …

2020年9月15日 · Severe hypoxia promotes GCs apoptosis through the JNK/FOXO1 signal pathway. Inhibition of the JNK/FOXO1 axis alleviates severe hypoxia-induced GCs apoptosis. …

2021年4月6日 · Therefore, we evaluated whether FoxO, the sole ortholog of the forkhead-box subgroup O family in Drosophila, is involved in airway remodeling because of JNK activation. …

JNK can act as a molecular switch that regulates FoxO-induced autophagy and apoptosis. FoxO transcription factors are implicated in the induction of both cell death (apoptosis) and cell …

Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, …

Our findings identify JNK-dependent modulation of mRNA stability as an important PKB-independent mechanism underlying FoxO1 regulation by cytokines, and suggest that reduced …

2024年6月20日 · Genetic epistasis analysis reveals that Tip60 acts downstream of JNK, paralleling with the transcription factor FOXO. The biochemical results confirm that Tip60 can …

2004年11月11日 · To confirm the role of JNK in transcriptional activation via T447/451 phosphorylation, we analyzed FOXO transcriptional activity in JNK1,2−/− cells. In these cells, …

Activation of c-Jun N-terminal kinase (JNK) signaling in neurons increases stress resistance and extends life span, in part through FOXO-mediated transcription in Drosophila. However, the …