A conserved motif in JNK/p38-specific MAPK phosphatases as a ... - Nature
2016年3月18日 · Here we report the crystal structure of JNK1 bound to the catalytic domain of MKP7 at 2.4-Å resolution, providing high-resolution structural insight into the FXF-docking …
The protective role of the MKP-5-JNK/P38 pathway in ... - PubMed
2019年9月1日 · Further, inhibition of JNK or P38 MAPK pathways resisted to glucolipotoxicity observed in MKP-5 knockdown MIN6 cells. These findings indicate that MKP-5 is an important …
MKP-7, a JNK phosphatase, blocks ERK-dependent gene …
2010年3月5日 · MAPK phosphatase-7 (MKP-7) was identified as a JNK-specific phosphatase. However, despite its high specificity for JNK, MKP-7 interacts also with ERK. We previously …
The protective role of the MKP-5-JNK/P38 pathway in
2019年9月1日 · Using gene overexpression and knockdown approaches, we demonstrated that MKP-5 could alleviate glucolipotoxicity-induced apoptosis via the endoplasmic reticulum (ER) …
MAPK Phosphatase-5 is required for TGF-β signaling through a JNK ...
2024年6月27日 · MKP-5 dephosphorylates the stress-responsive MAPKs, p38 MAPK and JNK, and has been shown to promote tissue fibrosis. Here, we provide insight into how MKP-5 …
Regulation of JNK and p38 MAPK in the immune system: Signal …
In response to TLR stimulation, MKP-1 −/− macrophages exhibited increased and prolonged activation of p38 and JNK, and produced excessive amounts of cytokines, including TNF-α, IL …
MKP-5-JNK/P38信号通路对胰岛β细胞糖脂毒性损伤的保护作用及 …
丝裂原活化蛋白激酶磷酸酶 (MAPK phosphatase,MKP),可以通过特异性去除苏氨酸和酪氨酸的磷酸化负向调控MAPK的活化。 MKP-5作为第三类MKPs,已经有文献报道MKP-5被干扰后,可以 …
MAPK Phosphatase-5 is required for TGF-β signaling through a JNK ...
2024年6月27日 · MKP-5 dephosphorylates the stress-responsive MAPKs, p38 MAPK and JNK, and has been shown to promote tissue fibrosis. Here, we provide insight into how MKP-5 …
The MAP kinase phosphatase MKP-1 regulates BDNF-induced …
2010年10月10日 · We found that MAP kinase phosphatase-1 (MKP-1) controls axon branching. MKP-1 expression induced by BDNF signaling caused spatiotemporal deactivation of c-jun N …
MKP-7, a negative regulator of JNK, regulates VCAM-1
2012年4月1日 · MKP-7 has been identified as a JNK-specific phosphatase (JNK ≫ p38 > ERK) with the characteristics of a nucleocytoplasmic shuttle protein [20]. In the present study, we …