2017年2月8日 · Overproduction of PPM1A suppressed apoptosis of Mtb- infected macrophages by a mechanism that involves inactivation of the c-Jun N-terminal kinase (JNK). Targeted depletion of PPM1A by shRNA or...

2015年2月2日 · Here we found that PtpA suppressed innate immunity dependent on pathways of the kinases Jnk and p38 and the transcription factor NF-κB by exploiting host ubiquitin. Binding of PtpA to ubiquitin...

2023年11月28日 · We demonstrate that Mtb infection results in muted phosphorylation of p38 and JNK, regulators of inflammation, and leverage our single-cell methods to distinguish between pathogen-mediated interference in host signaling and weak activation of host pathways.

2012年5月5日 · Enhanced intracellular survival (Eis) protein, secreted by Mtb, enhances survival of Mycobacterium smegmatis ( Msm) in macrophages. Mtb Eis was shown to suppress host immune defenses by negatively modulating autophagy, inflammation, and cell death through JNK-dependent inhibition of reactive oxygen species (ROS) generation.

2019年1月1日 · Mtb AcpM significantly decreased apoptosis/necrosis and enhanced intracellular bacterial survival by modulating ROS generation and the JNK signaling pathway. These findings enhance our understanding of Mtb survival within host macrophages and will facilitate development of novel therapeutics and vaccines against Mtb.

2012年5月15日 · We propose that Mtb Eis initiates the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS generation by acetylating DUSP16/MKP-7. Our work thus provides insight into the mechanism of suppressing host immune responses and enhancing mycobacterial survival within macrophages by Mtb Eis.

2018年4月15日 · PtkA programs macrophage through MEK-JNK-cJUN pathway. Mycobacterium tuberculosis (MTB) is a successful pathogen which increases persistence inside the host macrophage by subverting its defence mechanism. Mycobacteria regulate the pathogenesis and intracellular survival by controlling its interaction with host protein (s).

Leukotactin (Lkn)-1 is a CC chemokine and is upregulated in macrophages in response to Mycobacterium tuberculosis (MTB) infection. We investigated whether mitogen-activated protein kinases (MAPKs) are involved in MTB-induced expression of Lkn-1.

2017年2月8日 · PPM1A 的过量产生通过涉及 c-Jun N 末端激酶 (JNK) 失活的机制抑制了 Mtb 感染的巨噬细胞的凋亡。 通过 shRNA 靶向消除 PPM1A 或通过血 根碱抑制 PPM1A 活性可恢复 JNK 激活，导致 Mtb 感染的巨噬细胞凋亡增加。

2012年4月7日 · At home on inspection I found the rocker bearing was broken in half, it is Jnk (japan) bearing. Bike is only three days old, taking it back for free repair ! Any suggestions for better bearings.