c-Jun N-terminal kinases differentially regulate TNF- and TLRs …
2018年11月15日 · Here we showed that c-Jun N-terminal kinases (JNK1 and JNK2) displayed kinase-dependent and -independent functions in regulating TNF- and TLRs-mediated …
TNF and MAP kinase signaling pathways - PMC - PubMed …
Three groups of MAP kinases can be defined: ERK (extracellular signal-regulated kinase); JNK (c-Jun N-terminal kinase); and p38 MAP kinases. These pathways can be activated by many …
Inter-cell type interactions that control JNK signaling in the
2024年6月28日 · JNK signaling can be activated by environmental stresses (e.g., UV radiation, oxidative damage) and pro-inflammatory factors (e.g., TNFs), and plays critical roles in many …
Role of JNK activation in apoptosis: A double-edged sword
2005年1月1日 · In the absence of NF-κB activation, prolonged JNK activation contributes to TNF-α induced apoptosis. JNK is also essential for UV induced apoptosis. However, recent studies …
JNK potentiates TNF-stimulated necrosis by increasing the …
2021年12月1日 · We report that JNK has a dual role in the TNF-stimulated death of fibroblasts. JNK can suppress TNF-stimulated apoptosis, but can also potentiate TNF-stimulated necrosis. …
JNK activation is required for TNFα-induced apoptosis in human ...
These results demonstrate a causal role for JNK and caspases in TNF+CHX-induced apoptosis of Huh7 human hepatoma cells. Therefore, strategies aimed at enhancing both pathways should …
Tumor necrosis factor alpha-induced activation of c-jun N …
Our findings show that: (i) TNF-RII is able to activate two members of the MAP kinase family: extracellular regulated kinase (ERK) and c-jun N-terminal kinase (JNK); (ii) TRAF2, a molecule …
TNF and MAP kinase signalling pathways - PubMed
The binding of tumour necrosis factor α (TNFα) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: …
Tumor Necrosis Factor - Cell Press
2004年2月20日 · Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live …
TNF-α-JNK信号通路研究获进展 - 科学网
2012年1月18日 · 这项研究揭示了一种新的分子机制，即通过Miz1抑制TNF-α-JNK的激活可以通过自身特殊位点的遍在蛋白化和降解来进行脱阻抑。 林安宁研究组主要从事癌症信号转导网络 …