c-Jun N-terminal kinases - Wikipedia
c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser -63 and Ser-73 within its transcriptional activation domain. They belong to the …
Nuclear and cytosolic JNK signalling in neurons - Nature
2014年4月17日 · JNKs are sensors of stress, eliciting transcriptional responses in the nucleus and intrinsic death pathway responses in the cytosol, which communicate a strong pro-apoptotic …
JNK Signaling: Regulation and Functions Based on Complex …
2016年7月27日 · Here we review the current knowledge of JNK structure and isoforms as well as the partnerships of JNKs with a range of intracellular proteins. Many of these proteins are …
Targeting JNK for therapeutic benefit: from junk to gold?
2003年7月1日 · JNK's represent attractive targets for immunomodulatory drug development. Neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases, …
JNK signaling and its impact on neural cell maturation and ...
2024年8月1日 · C-Jun-N-terminal-kinases (JNKs), members of the mitogen-activated-protein-kinase family, are significantly linked with neurological and neurodegenerative pathologies and …
C-Jun N-terminal kinase inhibitors: Structural insight into kinase ...
2020年1月1日 · JNKs are serine/threonine kinases phosphorylating several substrates such as c-Jun and activating transcription factor 2. There are three closely related genes, JNK1, JNK2, …
The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases …
2021年9月6日 · c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, …
Unraveling the Design and Discovery of c-Jun N-Terminal Kinase
2022年3月10日 · c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, are encoded by three genes: jnk1, jnk2, and jnk3. JNKs are involved in …
JNK Signaling: Isoforms, Activation, Apoptosis, and Immunity
2024年10月7日 · JNK signaling, an integral component of the Mitogen-Activated Protein Kinase (MAPK) pathways, plays crucial roles in various cellular processes. Understanding this …
New insights into the structural dynamics of the kinase JNK3
2018年6月21日 · JNKs are serine/threonine kinases belonging to the evolutionary conserved mitogen-activated protein kinase (MAPK) family. JNKs are also known as stress-activated …
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