The oncogenic transcription factor c-Jun regulates glutaminase
2016年4月18日 · Here we report that the transcription factor c-Jun, product of the proto-oncogene JUN, is a key regulator of mitochondrial glutaminase (GLS) levels. Activation of c-Jun …
学懂通路第三期： MAPK信号通路 - 知乎 - 知乎专栏
JNK（JUN N -terminal kinases, JNK）主要包括JNK1/2/3，也称作SAPKs（stress-activated protein kinases）。 JNK/SAPK信号通路 可被应激刺激(如紫外线、热休克、高渗刺激及蛋白合 …
Dual therapeutic targeting of MYC and JUNB transcriptional
2024年8月19日 · The present study shows for the first time that MYC and JUNB, two crucial TFs implicated in MM pathogenesis, orchestrate distinct transcriptional programs.
VEGFA, MYC, and JUN are abnormally elevated in the synovial
2025年1月15日 · We speculate that Myc and VEGFA activate the p38-MAPK signaling pathway to further activate Jun, thereby promoting abnormal inflammation, proliferation, and angiogenesis …
c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc …
2004年2月6日 · Our former studies revealed that amino acids (aa) 127-189 of c-Myc are responsible for stress-induced stability of the c-Myc protein. This region of c-Myc shares …
DYRK2 priming phosphorylation of c-Jun and c-Myc modulates ... - PubMed
Here, we found that the dual-specificity tyrosine phosphorylation-regulated kinase DYRK2 functions as a priming kinase of c-Jun and c-Myc. Knockdown of DYRK2 in human cancer …
C-JUN 蛋白研究——表达和活性调节受多种蛋白激酶调节 - 知乎
C-JUN 蛋白 是属于 活化蛋白-1 （AP-1）转录复合物中的一种，是AP-1复合物中zui具有转录活性的转录因子，各种物理、化学、生物学刺激及细胞应激反应都可以通过促进C-JUN 蛋白表达 …
Nature：克服癌症研究中的艰巨挑战！给小分子化合物添加鱼钩成功靶向癌症靶标MYC、c-JUN …
2023年6月5日 · 癌基因myc被称为癌症研究的“珠穆朗玛峰”，因为设计能使它失效的药物非常困难，而且人们期望一种有效的myc药物能帮助如此多的癌症患者。 资讯 ...
Identification of Jun loss promotes resistance to histone …
2018年11月30日 · Jun -deleted samples, found in 17–23% of luminal patients, had significantly higher Myc signature scores that predicted worse survival. Entinostat inhibited luminal breast …
Oncogenic transcription factors: FOS, JUN, MYC, MYB, and ETS
2023年10月31日 · Transcription factors are critical components of signal transduction pathways that can transmit a regulatory signal to altered patterns of gene expression. It is not surprising …