IκB（inhibitor of NF-κB），是核因子κB（NF-κB）的抑制蛋白。 IκB家族由8个成员组成，分别是：p100、p105、IκBα、IκBβ、IκBγ、IκBε、Bcl-3和IκB-R，大部分IκB的 C端 含有3~8个 锚蛋 …

NF-kB在细胞因子诱导的基因表达中起关键性的调控作用，它调控的基因编码急性期反应蛋白、细胞因子、细胞粘附分子、免疫调节分子、病毒瘤基因、生长因子、转录和生长调控因子等。 …

We describe here how these studies have identified a unique inhibitor of pro-inflammatory NF- κ B signaling, an unforeseen role for IKK α in the classical NF- κ B pathway, and a novel functional …

In enzymology, an IκB kinase (EC 2.7.11.10) is an enzyme that catalyzes the chemical reaction: Thus, the two substrates of this enzyme are ATP and IκB protein, whereas its two products are …

2023年3月30日 · IKKs （IKKα、IKKβ)：IκB激酶，使IκB磷酸化并降解（蛋白酶体依赖的泛素化降解），释放p65与p50异二聚体，核定位序列暴露，快速入核。 多数情况下，NF-κB 二聚体激 …

当上游信号因子TNF结合到细胞膜表面受体后，受体构象改变并将信号传递给 IKK激酶 （IkB kinase），进而使IkB蛋白磷酸化并将其从三聚体中解离出来。 随后NF-κB二聚体暴露出核定 …

2 天之前 · T he NF- k B/I k B signaling system represents a unique example where a deep biophysical understanding of the protein interaction dynamics can be quantitatively linked to …

Rel/NF-kB transcription factors are primarily regulated by association with inhibitor IkB proteins. Thus, in most cells NF-kB exists in the cytoplasm in an inactive complex bound to IkB. Most...

Control over the immune cell functions of NF-κB results from signaling through one of two different routes: the canonical and noncanonical NF-κB signaling pathways. Present at the end of both …

New work reveals the roles of the three subunits of IKK and how it is regulated. NF-κB represents a family of transcription factors that are normally kept inactive in the cytoplasm through …