Production of unsulfated chondroitin and associated chondro ...
2024年10月1日 · The pathogenic Escherichia coli K4 strain produces a capsular fructosylated chondroitin, called K4 polysaccharide, synthesized by chondroitin synthase KfoC, which has …
Production of chondroitin in metabolically engineered E. coli
2015年1月1日 · This study proposes a safer and more feasible approach to metabolically engineer chondroitin production by expressing genes from the pathogenic E. coli K4 strain, …
Biotechnological advances in the synthesis of modified chondroitin ...
2023年10月1日 · Recent literature demonstrates that intracellular quantification of precursor UDP-sugars, that are necessary for fructosylated chondroitin biosynthesis in wild type and …
The Structural Basis for a Coordinated Reaction Catalyzed by a ...
The K4 strain of Escherichia coli-produced chondroitin synthase K4CP is one such bifunctional glycosyltransferase that catalyzes β1–3 glucuronyltransfer and β1–4-N …
KfoA, the UDP-glucose-4-epimerase of Escherichia coli strain O5:K4…
2017年11月20日 · E. coli O5:K4:H4 (ATCC 23502), also known as K4, is a uropathogenic strain, and its whole genome has been sequenced (Cress et al. 2013a). Its capsular polysaccharide, …
Molecular Cloning and Characterization of Chondroitin …
Escherichia coli strain K4 produces the K4 antigen, a capsule polysaccharide consisting of a chondroitin backbone (GlcUA β(1–3)-GalNAc β(1–4)) n to which β-fructose is linked at position …
JGI GOLD | Project
2014年10月31日 · We report the 4.682-Mbp high-quality draft assembly of the Escherichia coli strain ATCC #23502 (serovar O5:K4(L):H4, also known as NCDC U1-41) genome. This …
Chondroitin Sulfate and Its Derivatives: A Review of Microbial and ...
2022年7月10日 · Multiple bacterial strains have been used to make different types of chondroitin sulfate with varying yields. The most common strain used is E. coli K4 because it already …
Production and purification of higher molecular weight …
2020年8月6日 · In this work, we took advantage of recombinant E. coli K4 strains that overproduce capsular polysaccharide, to study whether the inferred pathway modifications …
New insight into chondroitin and heparosan-like ... - ScienceDirect
2017年2月28日 · Escherichia coli K4 and K5 capsular polysaccharides (K4 and K5 CPSs) have been used as starting material for the biotechnological production of chondroitin sulfate (CS) …
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