K-562 are lymphoblast cells isolated from the bone marrow of a 53-year-old chronic myelogenous leukemia patient. The K-562 cell line is widely used in immune system disorder and immunology research. Please fill out the form below to sign up for notification when the product becomes in stock. You were successfully signed up for notification.

established from the pleural effusion of a 53-year-old woman with chronic myeloid leukemia (CML) in blast crisis in 1970; cells carry the BCR-ABL1 e14-a2 (b3-a2) fusion gene; this subclone (ACC 10) weakly expresses MHC class I (image); other subclones (ACC 86 and ACC 92) are MHC class I negative and might be used in in-vitro natural killer assay...

Here, we have characterized K562 cells focusing on the karyotype of cells in prolonged culture, regulation of expression of TfR in wildtype (WT) and doxorubicin-resistant cells, and responses to histone deacetylase inhibition (HDACi).

2011年2月7日 · K562 is an erythroleukemia cell line that lacks HLA antigen expression. K562 cells have been shown to provide a cell contact-dependent co-stimulatory signal, enhancing the expansion of NK cells [52]. Combined with IL-2 and IL-15, …

K562 is widely used in biomedical research. It is one of three tier-one cell lines of ENCODE and also most commonly used for large-scale CRISPR/Cas9 screens. Although its functional genomic and epigenomic characteristics have been extensively ...

Complete karyotype characterization of the K562 cell line by combined application of G-banding, multiplex-fluorescence in situ hybridization, fluorescence in situ hybridization, and comparative genomic hybridization.

The paired K562-s and K562-r clones are useful cell line models of sensitivity and resistance to a tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia. It has applications in immune system disorder research.

2025年2月7日 · K562 cells are classified as an erythroleukemia cell line, exhibiting properties of both erythroid and leukemic cells. Their large size, round shape, high nucleus-to-cytoplasm ratio, and chromosomal abnormalities, including the Philadelphia chromosome, are …

2017年10月1日 · We have performed detailed analysis of the genomic landscape of commercially available K562 cells, employing targeted enrichment of nearly 1300 cancer-related genes followed by next-generation sequencing (NGS) and also classical cytogenetics. Deep sequencing revealed 88 variants of potentially biological significance.

2001年4月1日 · In applying this multimodal approach on the human leukemia cell line K562, the chromosome composition was refined in detail and compared with data from the literature. A hypotriploid karyotype with a modal chromosome number of 67, and 21 unique marker chromosomes were identified.