2023年11月1日 · Histone acetyltransferases (HATs) utilize acetyl-CoA as a coenzyme to catalyze the N-acetylation of lysine residues in histones H3 and H4.

2018年9月25日 · We identify 4 lysine butyrylation (Kbu) sites (H3K14, H4K12, H2BK42, and H2BK134) and 45 crotonylation (Kcr) sites on rice histones by mass spectrometry.

2016年4月21日 · We propose that at active gene TSSs, p300 (and possibly other HATs) randomly use acetyl- or butyryl-CoA to modify histone tails. HDACs and histone variants, also present at dynamic chromatin regions, accelerate the turnover of these histone marks.

2025年1月9日 · Epigenetic effects of butyrate and propionate have been attributed to histone deacetylase (HDAC) inhibition and to the activation of histone acetyl transferases (HATs) 4, 5, leading to increased...

2021年3月4日 · HATs are divided into three significant families by their sequence and structural features, such as Gcn5-related N-acetyltransferases (GNATs), the P300/CREB-binding protein (P300/CBP), and the MYST family (Moz, Ybf2, Sas2, and Tip60). ... For example, Kbu competitively inhibits Kac on H4K5 in spermatogenesis by restricting acetyl groups binding ...

2 天之前 · HATs 不仅调节组蛋白 Kcr，还控制许多非组蛋白 Kcr 修饰，影响关键的细胞通路。 例如，CBP 和 hMOF 强烈巴豆酰化非组蛋白 NPM1，PCAF 对其有中等程度的巴豆酰化活性；CBP 催化非组蛋白 DDX5 的 Kcr，而 p300、PCAF 和 hMOF 则无此活性。

Histone acetylation levels are co-regulated by HDACs (erasers) and HATs (writers). HATs are relatively distinct from each other. HDACs can be further classified as Class I, IIa, IIb, III, and IV.

2023年7月7日 · 到目前为止确定的新型蛋白质酰基化的“writer”和“eraser”都是之前定义的组蛋白乙酰基转移酶（HATs）和组蛋白去乙酰化酶（histone deacetylases, HDACs)。 既往研究表明异常的酰基化修饰与肿瘤、神经系统疾病、代谢性疾病等的发生和进展密切相关，HATs的小分子修饰剂表现出巨大的治疗潜力，但目前处于临床研究阶段的药物非常有限。 本文围绕组蛋白乙酰转移酶，主要综述了组蛋白和非组蛋白酰基化领域的最新发现，包括生物学功能及其与疾病的联系、 …

3 天之前 · Kcr writers. Crotonyltransferases, often called the "writers" of Kcr, play a key role in this modification [4, 20].With the well-characterized regulatory enzyme systems of acetylation in PTMs, histone acetyltransferases (HATs) were found to exhibit histone crotonyltransferase (HCT) activity [].Although it is noted in the literature that crotonyl …

近日，来自美国North Carolina大学的 Ian J. Davis教授 团队，在 Cell 子刊 Cell Reports 上，发表了题为“HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies”的研究长文。 研究人员 运用 定量蛋白质组学 技术，全面揭示了癌细胞在HDACi处理后在基因组层面和蛋白质组层面发生的改变。 结果发现HDACi会导致组蛋白H4的聚乙酰化，使得其成为含溴结构域蛋白更易结合的靶标，并且发现转录活跃的基因中的 …